IL4

IL4 also called BSF1 or BCGF-1, is a glycoprotein which is made up of 129 amino acids and has a molecular weight of 20kDa. This protein is an essential cytokine driving the differentiation of IL-4-producing Th2 cells from naïve T cells. A great variety of cells express IL4, such as Th2 cells, mast cells, basophils, type II innate lymphoid cells and NK T cells. IL4 serves an essential part in the promotion of allergic responses. And it is mainly related to promoting the differentiation and proliferation of T helper 2 (TH2) cells and the synthesis of immunoglobulin E (IgE).
In addition to its role in allergic responses including asthma, IL4 was also reported to modulate retinal progenitor proliferation, cholinergic and GABA-ergic amacrine differentiation, rod photoreceptor differentiation, as well as neuroprotection and survival. Importantly, IL4 has proven to have regulatory effects in a variety of neurological diseases, such as Multiple sclerosis, Alzheimer's disease, and experimental autoimmune encephalitis. Moreover, IL4 has also reported relieving inflammatory and neuropathic pain. It enables to play its biological activities by interaction with two cell surface receptor complexes-Type I IL4 receptor and Type II IL4 Receptor.

Gene ID: 3565
UniProt ID: P05112

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