IL5RA

IL5RA also known as CD125 or IL5R, is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. IL5RA is made up of a ligand specific alpha subunit and a signal transducing beta subunit shared via the receptors for colony stimulating factor 2 (CSF2/GM-CSF), interleukin 5 (IL5), as well as interleukin 3 (IL3). The binding of IL5RA to IL5 relies on the beta subunit. Moreover, the beta subunit is activated via the ligand binding, and is essential for the biological activities of IL5.
In general, this cytokine receptor has been reported to interact with syndecan binding protein (syntenin), which is needed for IL5 mediated activation of the transcription factor SOX4. Besides, IL5RA is a therapeutic target for hypereosinophilic diseases, such as allergic inflammations and asthma. It has been proven that Oct2 improves antibody-secreting cell differentiation by regulation of IL5RA expression on activated B cells. In addition, research has also demonstrated that an improved frequency of CD34+IL-5RA+progenitors correlates with an improvement in the generation of mature eosinophil numbers and the expansion of eosinophil precursors is a consistent observation in asthmatic patients.

Gene ID: 3568
UniProt ID: Q01344