ITGA2

Integrin subunit alpha 2 (ITGA2) also known as GPIa or CD49B, is the alpha 2 subunit of a transmembrane receptor for collagens and related proteins, which generates a heterodimer with β1 to produce α2β1. α2β1 is a cell adhesion molecule usually expressed on a variety of cell types, such as endothelial, haematopoetic cells, and epithelial cells. Nevertheless, rather than occurring ubiquitously, expression of ITGA2 exhibits both cell type and differentiation specificity.
An essential role for ITGA2 in cell migration, invasion, survival and angiogenesis is well established. In general, ITGA2 serves a crucial role in tumour cell invasion, metastasis and angiogenesis, and changed the expression of the receptor has been related to tumour prognosis in a number of solid tumours. Nevertheless, the relationship is complex, with both enhanced and reduced expression associated with different stages of tumour metastases in several tumour types. In addition, ITGA2 has been proven to regulate tumour cell invasion in pancreatic cancer, prostate tumours, and ovarian tumours; along with improved α2 related to decreased survival in melanoma and improved metastasis in colorectal cancer.

Gene ID: 3673
UniProt ID: P17301

If you can’t find your product on this list? Please directly send email to

For Research Use Only. NOT FOR CLINICAL USE.


Online Inquiry
Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
Project Description:









Customized FluoroAb™

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Contact us
USA
 
 Tel:
 Fax:
 Email:
Europe
 
 Tel:
 Email:
Germany
 
 Tel:
 Email:


Inquiry

Top