ITGA5

Integrin subunit alpha 5 (ITGA5), also known as FNRA or CD49e, encoded by ITGA5 gene, is a member of the integrin alpha chain family. It contains an extracellular structural domain that identifies the extracellular signal molecules, a cytoplasmic C-terminal tail that communicates with cytoskeletal component (α-actinin, talin, vinculin……), and a transmembrane domain that is a linker of the extracellular and intracellular region. The ITGA5 can combine with beta subunit forming an integrin which involves a variety of signal transduction pathway, including cell adhesion, migration, growth, survival and death.

The ITGA5 is widely expressed in multiple tissues, including appendix, esophagus, gallbladder, lung, placenta, prostate, and urinary bladder. Numerous studies have been shown that ITGA5, as a member of integrin alpha chain, plays an important role in many physiological and pathologic processes, contained inflammation, embryonic development, cell-cell adhesion and migration, wound healing, various cancer progression and migration, such as lung cancer, breast cancer, esophageal squamous cell carcinoma and so on.
Gene ID: 3678
UniProt ID: P08648