LAMP1

Lysosomal associated membrane protein 1 (LAMP1), also known as CD107a or LGP120, is a cell membrane glycoprotein that primarily resides across the lysosomal membranes. The major portion of LAMP1 is heavily N-glycosylated. It is exposed at lysosomal membrane surface and serves as carbohydrate ligands donor for selectins.

LAMP1 is actively expressed at medium or high level at various tissues and it is found at the cell surface due to lysosome-cell membrane fusion. LAMP1 is speculated to mediate cell-cell adhesion and its abnormal expression or mutation is also associated with tumor cell differentiation and metastasis. It has been reported that the adhesion of some cancer cells to the extracellular matrix is facilitated and mediated by LAMP1 and E-selectin interactions, in which LAMP1 plays the role as ligands for the cell-adhesion molecules. Currently, the cell surface expression of LAMP1 is reported to contribute to several cancers, including human astrocytoma, colon adenocarcinoma, fibrosarcoma, melanoma, and pancreatic adenocarcinoma.

Entrez Gene ID: 3916
UniProt ID: A0A024RDY3