LTA

Lymphotoxin alpha (LTA), also known as LT or TNFB, encoded by LTA gene, is a member of the tumor necrosis factor family. It is found that LTA can significantly affect the formation of secondary lymphoid organs during development and involve in cell apoptosis. Besides, LTA can also regulate kinds of inflammatory, immunostimulatory, and antiviral responses. The study has been shown that LTA participates in the process of killing inflammatory cells by activating cytotoxic T cells and macrophages. What's more, lymphotoxin (LT)-pathway has also been proved to regulate the host defense via the production of IL-22 and IL-23 in adult innate lymphoid cells.
The LTA is widely expressed in multiple human tissues, such as appendix, bone marrow, lymph node, spleen, testis and urinary bladder. It is proved that the LTA is associated with the progression of diseases, including ankylosing spondylitis, leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, psoriatic arthritis, ischemic stroke, sepsis, oral cancer and precancerous lesions, lupus erythematosus, persistent primary immune thrombocytopenia, hidradenitis suppurativa.
Gene ID: 4049
UniProt ID: P01374