LY6E

Lymphocyte antigen 6 family member E (LY6E), also known as stem cell antigen 2 (SCA2) and
thymic shared antigen-1 (TSA-1) or RIGE, is a member of the lymphostromal cell membrane Ly6 superfamily. All Ly6 family members are low-molecular weight (10-12 kDa) proteins that display limited nucleotide and amino acid sequence homologies with one another. However, they do share a commonly conserved cysteine-rich cell surface domain and are anchored to the cell surface via a glycosilphosphatidylinositol (GPI) moiety

It is demonstrated that LY6E plays a crucial role in cell-cell adhesion, signaling transduction via the
T cell receptor, and T cell development. This protein is also reported to be implicated in the malignant progression of various types of cancers, including Leukemia, breast cancers… However, the mechanism of how LY6E promotes malignant phenotypes and accelerates tumor growth still remains unclear. In addition to cancer biological functions, LY6E is reported to enhance cellular infection by a subset of enveloped RNA viruses from diverse families, including yellow fever virus, influenza A virus, vesicular stomatitis virus and so on.

Gene ID: 4061
UniProt ID: Q16553