MELTF

MELTF (Melanotransferrin), also known as MTF, CD228, melanoma-associated antigen p97, MAP97 or MFI2, is a cell surface localized glycoprotein that belongs to the transferrin family. According to the previous studies, most transferrins are designated for secretion after expression but MELTF is usually found tethered to the cell membrane by a glycosyl phosphatidyl inositol anchor.

Similar to other transferrins, MELTF is an iron-binding protein. Function wise, it may be associated with cellular proliferation, tumorigenesis, metastasis and migration. MELTF is highly expressed on melanoma cells, while its expression level is found to be lower in salivary gland, pancreas, kidney and testis. The unique expression of MELTF makes it an appealing target for antibody-based immunotherapies.

Entrez Gene ID: 4241
UniProt ID: P08582