NCA-90

Human granulocytes express a variety of nonspecific cross-reacting antigens (NCA). These proteins are glycoproteins and belong to the carcinoembryonic antigen (CEA) family. NCAs have been identified in a variety of normal and cancerous epithelial cells and also in hematopoietic cells including granulocytes and monocytes NCA-90 in tumors correlates inversely with cellular differentiation and is an independent prognostic factor associated with a higher risk of colorectal cancer relapse. NCA-90 is also an important protein associated with cell adhesion; its expression on neutrophils is involved in adhesion to cytokine-activated endothelial cells. This molecule correlates with other members of the CEA family with homotypic and heterotypic interactions.

NCA-90 inhibits anoikis, a form of programmed cell death that occurred in anchorage-dependent cells. The modulation of NCA-90 expression alters the malignant phenotype of cancer cells. The disruption of the NCA-90 gene down-regulates the Akt cell survival pathway. In addition, deficiency of NCA-90 enhances cell anoikis, increases caspase activation in response to anchorage-independent conditions, and inhibits metastasis in vivo. Expression of this membrane protein is also associated with increased invasiveness through a c-src-dependent mechanism. Thus, NCA-90 may represent a therapeutic target to control malignancy and/or metastasis.

If you can’t find your product on this list? Please directly send email to

For Research Use Only. NOT FOR CLINICAL USE.


Online Inquiry
Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
Project Description:









Customized FluoroAb™

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Contact us
USA
 
 Tel:
 Fax:
 Email:
Europe
 
 Tel:
 Email:
Germany
 
 Tel:
 Email:


Inquiry

Top