NCAM1

Neural cell adhesion molecule 1 (NCAM1), also known as CD56, NCAM or MSK39, is a cell adhesion protein that belongs to the immunoglobulin superfamily. NCAM-1 is a multifunctional molecule and it has been implicated in cell adhesion, neurite outgrowth, synaptic plasticity, and learning and memory. It is also involved in the expansion of T cells and dendritic cells which play a crucial role in immune surveillance.

This protein appears on early embryonic cells and plays an important role in the formation of cell collectives and their boundaries at sites of morphogenesis. This protein is also expressed on the surface of various normal and differentiated tissues that include neurons, glia, skeletal muscle and natural killer cells. What's more, there are a large number of tumors that exhibit CD56-positivity, such as Myeloma, Myeloid Leukemia, Neuroendocrine tumors, neuroblastoma, NK/T cell lymphomas, pancreatic acinar cell carcinoma, pheochromocytoma, paraganglioma, small cell lung carcinoma… Therefore, NCAM1 has been widely used as a target molecule for different cancer immunotherapy strategies, including therapeutic monoclonal antibody, immunotoxin as well as antibody-drug conjugate(ADC).

Gene ID: 4684
UniProt ID: P13591

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-460  Anti-NCAM1 (clone huN901)-SPP-DM1 ADC Lorvotuzumab mertansine (IMGN901) Anti-NCAM1 lgG1 Antibody, clone # huN901 SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate) DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-597 Anti-NCAM1 (clone huN901)-SPP-[3H]DM1 ADC Humanized Anti-NCAM1 Antibody, clone # huN901 SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate) [3H]DM1([3H]N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine) Inquiry
ADC-W-598 Anti-CD56 (clone huN901)-SMCC-[3H]DM1 ADC Humanized Anti-NCAM1 Antibody, clone # huN901 SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) [3H]DM1([3H]N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine) Inquiry
ADC-W-599 Anti-CD56 (clone huN901)-SPDB-[3H]DM1 ADC Humanized Anti-NCAM1 Antibody, clone # huN901 SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) [3H]DM1([3H]N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine) Inquiry
ADC-W-2342 Anti-NCAM1 (Lorvotuzumab )-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-NCAM1 IgG1-kappa antibody, Lorvotuzumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-2620 Anti-NCAM1 (Lorvotuzumab )-SMCC-DM1 ADC Humanized Anti-NCAM1 IgG1-kappa antibody, Lorvotuzumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-2621 Anti-NCAM1 (Lorvotuzumab )-SPDB-DM4 ADC Humanized Anti-NCAM1 IgG1-kappa antibody, Lorvotuzumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-2622 Anti-NCAM1 (Lorvotuzumab )-MC-MMAF ADC Humanized Anti-NCAM1 IgG1-kappa antibody, Lorvotuzumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-2623 Anti-NCAM1 (Lorvotuzumab )-MC-Vc-PAB-MMAE ADC Humanized Anti-NCAM1 IgG1-kappa antibody, Lorvotuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-2624 Anti-NCAM1 (Lorvotuzumab )-MC-Vc-PAB-SN38 ADC Humanized Anti-NCAM1 IgG1-kappa antibody, Lorvotuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
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