NOTCH2

NOTCH2 is a member of the NOTCH family that is contains repeated extracellular EGF domains and the notch domains. NOTCH2 belongs to the type I transmembrane family. It shares with other members of the family structural characteristics such as an intracellular domain and an extracellular domain. The intracellular domain is composed of multiple epidermal growth factor-like repeats while the extracellular domain consists of multiple, different domain types. NOTCh2 is cleaved in the trans-Golgi network and presented on the cell surface as a heterodimer. NOTCH2 functions as a receptor and play a role in vascular renal and hepatic development.
NOTCH2 plays specific roles in the immune compartment independently of and cooperatively with NOTCH1 and NOTCH3. Conditional inactivation of NOTCH2 in the B cell lineage results in defective MZB cell development. Lunatic fringe and Manic fringe are homologs of the fringe gene that modulates dorsal-ventral cell interactions in the developing wing in Drosophila. These two proteins are reported to cooperatively enhance Dll1-NOTCH2 interaction and thereby induce MZB development.
In addition, during T cell differentiation, NOTCH signaling is an essential component for functional maturation and activation of peripheral T cells, in which NOTCH2 is the main player. NOTCH2 expression is increased along with activation of CD8+ cytotoxic T lymphocytes.

Entrez Gene ID: 4853
UniProt ID: Q04721