PDCD1

Programmed cell death 1 (PDCD1), also known as PD1 or CD279, encoded by PDCD1 gene, is a surface membrane protein of the immunoglobulin superfamily. It is expressed on the surface of T cells, B cells and macrophages, induced by T cell receptor (TCR) or B cell receptor signaling. The surface protein is composed of a single immunoglobulin variable-like region and a cytoplasmic domain including two tyrosine-based signaling motifs5. The PDCD1 can be associated with its ligands (PD-L1 or PD-L2) to regulate self-reactive T cells or B cells and inflammatory responses.
The PDCD1 is widely expressed in multiple human tissues, such as lymph node, spleen, appendix, stomach, urinary bladder, gall bladder, heart. The PDCD1, as a surface receptor of immunoglobulin, is related to multiple pathological processes of immunological diseases, including autoimmune diseases, rheumatoid arthritis, non-Hodgkin lymphoma, various types of cancer. It is proved that the binding of PDCD1 and its ligands will transmit a negative signal to T cell, leading to deficiency of T cell function, decreased T cell proliferation, thus disarming immune response to cancer cells, resulting in cancer cells growth without regulation. These suggest that PDCD1 can be regarded as a therapeutic target applied to treat lots of diseases.
Gene ID: 5133
UniProt ID: Q15116

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-1694 Anti-PDCD1 (Nivolumab)-SMCC-DM1 ADC Human Anti-PDCD1 IgG4-kappa antibody, Nivolumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1695 Anti-PDCD1 (Nivolumab)-SPDB-DM4 ADC Human Anti-PDCD1 IgG4-kappa antibody, Nivolumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1696 Anti-PDCD1 (Nivolumab)-MC-MMAF ADC Human Anti-PDCD1 IgG4-kappa antibody, Nivolumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1697 Anti-PDCD1 (Nivolumab)-MC-Vc-PAB-MMAE ADC Human Anti-PDCD1 IgG4-kappa antibody, Nivolumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1698 Anti-PDCD1 (Nivolumab)-MC-Vc-PAB-SN38 ADC Human Anti-PDCD1 IgG4-kappa antibody, Nivolumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1699 Anti-PDCD1 (Nivolumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Human Anti-PDCD1 IgG4-kappa antibody, Nivolumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-1700 Anti-PDCD1 (Pidilizumab)-SMCC-DM1 ADC Humanized Anti-PDCD1 IgG1-kappa antibody, Pidilizumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1701 Anti-PDCD1 (Pidilizumab)-SPDB-DM4 ADC Humanized Anti-PDCD1 IgG1-kappa antibody, Pidilizumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1702 Anti-PDCD1 (Pidilizumab)-MC-MMAF ADC Humanized Anti-PDCD1 IgG1-kappa antibody, Pidilizumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1703 Anti-PDCD1 (Pidilizumab)-MC-Vc-PAB-MMAE ADC Humanized Anti-PDCD1 IgG1-kappa antibody, Pidilizumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1704 Anti-PDCD1 (Pidilizumab)-MC-Vc-PAB-SN38 ADC Humanized Anti-PDCD1 IgG1-kappa antibody, Pidilizumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1705 Anti-PDCD1 (Pidilizumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-PDCD1 IgG1-kappa antibody, Pidilizumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-2210 Anti-PDCD1 -SMCC-DM1 ADC Humanized Anti-PDCD1 IgG4-kappa antibody SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-2211 Anti-PDCD1 -SPDB-DM4 ADC Humanized Anti-PDCD1 IgG4-kappa antibody SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-2212 Anti-PDCD1 -MC-MMAF ADC Humanized Anti-PDCD1 IgG4-kappa antibody MC (maleimidocaproyl) MMAF Inquiry
ADC-W-2213 Anti-PDCD1 -MC-Vc-PAB-MMAE ADC Humanized Anti-PDCD1 IgG4-kappa antibody MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-2214 Anti-PDCD1 -MC-Vc-PAB-SN38 ADC Humanized Anti-PDCD1 IgG4-kappa antibody MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-2215 Anti-PDCD1 -MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-PDCD1 IgG4-kappa antibody MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
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