PDGFRA

Platelet-derived growth factor receptor alpha (PDGFRA), also known as CD140A or PDGFR2, encoded by PDGFRA gene, is a cell surface tyrosine kinase receptor which belongs to platelet-derived growth factor family. The monomer PDGFRA can bind to monomer PDGFRA or PDGFRB to form a homodimer or a heterodimer with different affinities with four ligands (PDGFA–D). The PDGFR dimers generate autophosphorylation via ligand binding and receptor dimerization, stimulating downstream signaling through the MAPK, PI3K-AKT, and PLCγ pathways. Previous studies have been revealed that PDGFRA plays a role in organ development, wound healing, and tumor progression.
The PDGFRA is ubiquitously expressed in multiple human tissues, such as ovary, appendix, brain, endometrium, gallbladder, placenta, spleen, urinary bladder. It has been shown that PDGFRA is associated with idiopathic hypereosinophilic syndrome, chronic myeloid leukemia, hepatocellular carcinoma, somatic and familial gastrointestinal stromal tumors, metastatic colorectal cancer, glioblastoma and other cancers. These also indicate that PDGFRA can be regarded as a therapeutic target applied to treat various cancer.
Gene ID: 515
UniProt ID: P16234