Pseudomonas Aeruginosa Serotype IATS O11

Pseudomonas aeruginosa is the pathogen responsible for approximately 20% of ventilator-associated pneumonia (VAP) and is one of the most difficult pathogens to treat. VAP caused by P. aeruginosa has the poorest outcome of all intensive care unit (ICU) infections. Lipopolysaccharide (LPS) is an important virulence factor in P. aeruginosa, exerting direct endotoxic effects. The tripartite nature of LPS divides the molecule into a hydrophobic lipid A region, a central core oligosaccharide region, and a repeating polysaccharide portion referred to as O antigen or O polysaccharide. The complete serotyping system for P. aeruginosa, the International Antigenic Scheme (IATS), consists of 20 standard O serotypes. Current epidemiology data indicate that, of these 20 serotypes, IATS O1, serogroup 2 (IATS O2, IATS O5, and IATS 16), IATS O6, and IATS O11 are responsible for 70% of P. aeruginosa infections.
One of the toxins secreted by the type III secretion system (TTSS), were frequently serotyped as IATS O11. Serotype IATS O11 strains are common in the environment and in hospital outbreaks and have been shown to be adherent and cytotoxic, and even exhibit multidrug resistance.

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