ROR1

Receptor tyrosine kinase like orphan receptor 1 (ROR1), also known as dJ537F10.1, neurotrophic tyrosine kinase receptor-related 1 (NTRKR1), is a glycosylated type I membrane protein that belongs to the ROR family of receptor tyrosine kinases. The ROR family are characterized by the extracellular immunoglobulin domain, cysteine-rich domain that resembles the Wnt-binding sites of Frizzled proteins, kringle domain and intracellular kinase domain. The ROR1 gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. The exact function of this protein remains unclear, but several researches implicated that ROR1 protein is a pseudokinase lacking catalytic activity and may interact with the non-canonical Wnt signalling pathway. What's more, the increased expression of this gene is found in B-cell chronic lymphocytic leukaemia and ovarian cancer stem cell. Therefore, ROR1 protein can serve as a promising target for cancer immunotherapy strategies, such as monoclonal antibody and immunotoxin. There are study shows that treatment with a humanized monoclonal antibody specific for ROR1 could inhibit the capacity of ovarian cancer cells to migrate, form spheroids, or engraft immune-deficient mice.

Gene ID: 4919
UniProt ID: Q13433

If you can’t find your product on this list? Please directly send email to

For Research Use Only. NOT FOR CLINICAL USE.


Online Inquiry
Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
Project Description:









Customized FluoroAb™

Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.

Contact us
USA
 
 Tel:
 Fax:
 Email:
Europe
 
 Tel:
 Email:
Germany
 
 Tel:
 Email:


Inquiry

Top