SLAMF7

SLAM family member 7 (SLAMF7), also known as CRACC or CD319, encoded by SLAMF7 gene, is a 66kDa glycoprotein member of the SLAM superfamily. It contains a membrane proximal C-type Ig fold and a membrane distal V-type Ig, a cytoplasmic region including two immunoreceptor tyrosine-based switch motifs (ITSM). The phosphorylation of tyrosine-based motifs in SLAMF7 induces downstream molecules activation including PLCγ1, PLCγ2 and PI3K kinases, regulating a variety of cell functions. It has shown that SLAMF7 can be considered as a signaling lymphocyte activation molecule which expresses on immune cells to mediate host defense via depression of the proinflammatory cytokines production. In addition, SLAMF7 may exert a negative and positive regulatory effect on natural killer cells.
The SLAMF7 is widely expressed in multiple human tissues, such as lymph node, appendix, colon, duodenum, small intestine, spleen, stomach, urinary bladder. A number of studies have been shown that SLAMF7 is associated with various inflammatory diseases, including systemic lupus erythematosus, rheumatoid arthritis, periodontitis, multiple myeloma. These suggest that SLAMF7 can be considered as a therapeutic target to apply to treat the kinds of inflammatory diseases.
Gene ID: 57823
UniProt ID: Q9NQ25