STEAP

STEAP family member 1 (STEAP1, or Six Transmembrane Epithelial Antigen of the Prostate 1), also known as STEAP or PRSS24, is a ubiquitously expressed cell membrane STEAP family protein (a six-transmembrane protein) that contains one ferric oxidoreductase domain. Functionally, STEAP1 is a metalloreductase that reduces the oxidative status of metal ions, for instance Fe3+ to Fe2+ and Cu2+ to Cu+, using NAD+ as a proton acceptor, a mechanism that places STEAP1 in the mineral absorption pathways. Besides metalloreductase activity, STEAP1 has also been shown to present at cell-cell junctions as a cell surface antigen and it is believed to serve as a channel between cells.

STEAP1 expression is highly tumor-related. High level of STEAP1 was observed in several human cancer cell lines including prostate, breast, pancreas, bladder, gastrointestinal tract, testis, ovary, cervix, Ewing sarcoma, and melanomas. It is also associated with malignant tumors from several tissues, including prostate, breast, bladder, lung. Currently, STEAP1 is used as a target for antibody-drug conjugates development.

Entrez Gene ID: 26872
UniProt ID: Q9UHE8

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