TGFB2

Transforming growth factor-beta 2 (TGFB2) is an extracellular glycosylated protein that has multiple cellular functions and plays an important role during embryonic development. It is also known as glioblastoma-derived T-cell suppressor factor, G-TSF and BSC-1 cell growth inhibitor. The crystal structure of the TGF-beta 2 monomer lacks a well-defined hydrophobic core and displays an unusual elongated non-globular fold. Eight cysteine residues form four intra-chain disulfide bonds, creating the characteristic knotted arrangement. The dimer is stabilized by a ninth cysteine, which forms an inter-chain disulfide bond, and by two identical hydrophobic interfaces.
TGFB1 and TGFB2 have been found in porcine platelets. In both bovine bone and porcine platelets, TGFB2 is less abundant than TGFB1, constituting only approximately 18% of the total recovered TGFB. Moreover, TGFB2 has the remarkable sequence conservation with TGFB1. A number of studies reveal that TGFB2 is involved in apoptotic pathways in Synovial Fibroblasts and PAK Pathway. TGFB2 is reported to be associated with several diseases which include Holt-Oram Syndrome, an autosomal dominant disorder that affects bones in the arms and hands (the upper limbs) and may also cause heart problems.
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Entrez Gene ID: 7042
UniProt ID: P61812

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-1808 Anti-TGFB2 (Lerdelimumab)-SMCC-DM1 ADC Human Anti-TGFB2 IgG4 antibody, Lerdelimumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1809 Anti-TGFB2 (Lerdelimumab)-SPDB-DM4 ADC Human Anti-TGFB2 IgG4 antibody, Lerdelimumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1810 Anti-TGFB2 (Lerdelimumab)-MC-MMAF ADC Human Anti-TGFB2 IgG4 antibody, Lerdelimumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1811 Anti-TGFB2 (Lerdelimumab)-MC-Vc-PAB-MMAE ADC Human Anti-TGFB2 IgG4 antibody, Lerdelimumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1812 Anti-TGFB2 (Lerdelimumab)-MC-Vc-PAB-SN38 ADC Human Anti-TGFB2 IgG4 antibody, Lerdelimumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1813 Anti-TGFB2 (Lerdelimumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Human Anti-TGFB2 IgG4 antibody, Lerdelimumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
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