TNFRSF10B

TNF receptor superfamily member 10b (TNFRSF10B), also known as Death receptor 5 (DR5), CD262, KILLER, TRICK2, TRICKB, ZTNFR9 or TRAIL receptor 2 (TRAILR2), is a type 1 membrane protein that belongs to the TNF-receptor superfamily. The TNFRSF10B gene encodes a 440-amino acid residue precursor protein containing extracellular cysteine-rich domains, a transmembrane domain and a cytoplasmic death domain. The TNFRSF10B protein is a receptor for tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L) and it can be activated by those ligands. After activation, the adapter molecule FADD recruits caspase-8 to the activated receptor to form the death-inducing signaling complex (DISC), resulting in caspase-8 proteolytic activation and the subsequent cascade of caspases mediating apoptosis.

This protein is widely expressed in numerous tissues, such as heart, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, stomach, intestinal tract as well as peripheral blood lymphocytes, and it is highly expressed in tumor cell lines that include HeLaS3, K-562, HL-60, SW480, A-549 and G-361. Notably, monoclonal antibodies targeting TNFRSF10B have been developed and are currently under clinical trials for patients suffer from a variety of cancer types, for example, Tigatuzumab (also called CS-1008).

Gene ID: 8795
UniProt ID: O14763

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-387 Anti-TNFRSF10B (hTRA-8)-Mc-MMAF ADC Anti-TNFRSF10B Antibody, hTRA-8 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-388 Anti-TNFRSF10B (hTRA-8)-VC-MMAF ADC Anti-TNFRSF10B Antibody, hTRA-8 VC (valine-citrulline) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-1862 Anti-TNFRSF10B (Conatumumab)-SMCC-DM1 ADC Human Anti-TNFRSF10B IgG1-kappa antibody, Conatumumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1863 Anti-TNFRSF10B (Conatumumab)-SPDB-DM4 ADC Human Anti-TNFRSF10B IgG1-kappa antibody, Conatumumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1864 Anti-TNFRSF10B (Conatumumab)-MC-MMAF ADC Human Anti-TNFRSF10B IgG1-kappa antibody, Conatumumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1865 Anti-TNFRSF10B (Conatumumab)-MC-Vc-PAB-MMAE ADC Human Anti-TNFRSF10B IgG1-kappa antibody, Conatumumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1866 Anti-TNFRSF10B (Conatumumab)-MC-Vc-PAB-SN38 ADC Human Anti-TNFRSF10B IgG1-kappa antibody, Conatumumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1867 Anti-TNFRSF10B (Conatumumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Human Anti-TNFRSF10B IgG1-kappa antibody, Conatumumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-1868 Anti-TNFRSF10B (Drozitumab)-SMCC-DM1 ADC Human Anti-TNFRSF10B IgG1-lambda antibody, Drozitumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1869 Anti-TNFRSF10B (Drozitumab)-SPDB-DM4 ADC Human Anti-TNFRSF10B IgG1-lambda antibody, Drozitumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1870 Anti-TNFRSF10B (Drozitumab)-MC-MMAF ADC Human Anti-TNFRSF10B IgG1-lambda antibody, Drozitumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1871 Anti-TNFRSF10B (Drozitumab)-MC-Vc-PAB-MMAE ADC Human Anti-TNFRSF10B IgG1-lambda antibody, Drozitumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1872 Anti-TNFRSF10B (Drozitumab)-MC-Vc-PAB-SN38 ADC Human Anti-TNFRSF10B IgG1-lambda antibody, Drozitumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1873 Anti-TNFRSF10B (Drozitumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Human Anti-TNFRSF10B IgG1-lambda antibody, Drozitumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-1874 Anti-TNFRSF10B (Lexatumumab)-SMCC-DM1 ADC Human Anti-TNFRSF10B IgG1-lambda antibody, Lexatumumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1875 Anti-TNFRSF10B (Lexatumumab)-SPDB-DM4 ADC Human Anti-TNFRSF10B IgG1-lambda antibody, Lexatumumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1876 Anti-TNFRSF10B (Lexatumumab)-MC-MMAF ADC Human Anti-TNFRSF10B IgG1-lambda antibody, Lexatumumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1877 Anti-TNFRSF10B (Lexatumumab)-MC-Vc-PAB-MMAE ADC Human Anti-TNFRSF10B IgG1-lambda antibody, Lexatumumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1878 Anti-TNFRSF10B (Lexatumumab)-MC-Vc-PAB-SN38 ADC Human Anti-TNFRSF10B IgG1-lambda antibody, Lexatumumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1879 Anti-TNFRSF10B (Lexatumumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Human Anti-TNFRSF10B IgG1-lambda antibody, Lexatumumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-1880 Anti-TNFRSF10B (Tigatuzumab)-SMCC-DM1 ADC Humanized Anti-TNFRSF10B IgG1 antibody, Tigatuzumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1881 Anti-TNFRSF10B (Tigatuzumab)-SPDB-DM4 ADC Humanized Anti-TNFRSF10B IgG1 antibody, Tigatuzumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1882 Anti-TNFRSF10B (Tigatuzumab)-MC-MMAF ADC Humanized Anti-TNFRSF10B IgG1 antibody, Tigatuzumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1883 Anti-TNFRSF10B (Tigatuzumab)-MC-Vc-PAB-MMAE ADC Humanized Anti-TNFRSF10B IgG1 antibody, Tigatuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1884 Anti-TNFRSF10B (Tigatuzumab)-MC-Vc-PAB-SN38 ADC Humanized Anti-TNFRSF10B IgG1 antibody, Tigatuzumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1885 Anti-TNFRSF10B (Tigatuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Humanized Anti-TNFRSF10B IgG1 antibody, Tigatuzumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry

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