TNFRSF8
TNF receptor superfamily member 8 (TNFRSF8), also known as CD30, Ki-1 or D1S166E, is a cell membrane protein of the tumor necrosis factor receptor family and functions as the receptor for TNFSF8/CD30L. This protein is expressed by activated, but not by resting, T and B cells. Interacting with TRAF2 and TRAF5, this receptor can mediate the signal transduction that leads to the activation of NF-kappaB and regulation of gene expression. In addition to being a positive regulator of apoptosis, this receptor also plays a role in protecting the body against autoimmunity by limiting the proliferative potential of autoreactive CD8 effector T cells.
This receptor is commonly expressed in various tumors, such as Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL), testicular embryonal carcinoma, therefore, it is widely used as a tumor marker in targeted immune therapy.
Gene ID: 943
UniProt ID: P28908
If you can’t find your product on this list? Please directly send email to
For Research Use Only. NOT FOR CLINICAL USE.
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
