TNFRSF8

TNF receptor superfamily member 8 (TNFRSF8), also known as CD30, Ki-1 or D1S166E, is a cell membrane protein of the tumor necrosis factor receptor family and functions as the receptor for TNFSF8/CD30L. This protein is expressed by activated, but not by resting, T and B cells. Interacting with TRAF2 and TRAF5, this receptor can mediate the signal transduction that leads to the activation of NF-kappaB and regulation of gene expression. In addition to being a positive regulator of apoptosis, this receptor also plays a role in protecting the body against autoimmunity by limiting the proliferative potential of autoreactive CD8 effector T cells.

This receptor is commonly expressed in various tumors, such as Hodgkin lymphoma (HL), anaplastic large cell lymphoma (ALCL), testicular embryonal carcinoma, therefore, it is widely used as a tumor marker in targeted immune therapy. This receptor is the target of the FDA approved therapeutic brentuximab Vedotin (Adcetris), an antibody drug conjugate (ADC) that is approved for the treatment of patients with HL and systemic ALCL.

Gene ID: 943
UniProt ID: P28908

Catalog Product name Similar to Antibody Linker Payload Data sheet Inquiry
ADC-W-354 Anti-TNFRSF8 (clone Ki4) scFv-MAP ADC Anti-TNFRSF8 Antibody scFv, clone # Ki4(scFv) human pro-apoptotic effector protein, microtubule-associated protein tau (MAPT) Inquiry
ADC-W-465  Anti-TNFRSF8 (Brentuximab)-VC-PAB-MMAE ADC Brentuximab Vedotin Anti-TNFRSF8 Antibody, Brentuximab VC-PAB (valine-citrulline with PAB) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-252 Anti-TNFRSF8 (Brentuximab-HC-F126)-DBCO-MMAF ADC Anti-TNFRSF8 antibody, Brentuximab variant, HC-F126 DBCO (Dibenzocyclooctyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-248 Anti-TNFRSF8 (Brentuximab-HC-K121)-DBCO-MMAF ADC Anti-TNFRSF8 antibody, Brentuximab variant, HC-K121 DBCO (Dibenzocyclooctyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-250 Anti-TNFRSF8 (Brentuximab-HC-K133)-DBCO-MMAF ADC Anti-TNFRSF8 antibody, Brentuximab variant, HC-K133 DBCO (Dibenzocyclooctyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-253 Anti-TNFRSF8 (Brentuximab-HC-P127)-DBCO-MMAF ADC Anti-TNFRSF8 antibody, Brentuximab variant, HC-P127 DBCO (Dibenzocyclooctyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-251 Anti-TNFRSF8 (Brentuximab-HC-S157)-DBCO-MMAF ADC Anti-TNFRSF8 antibody, Brentuximab variant, HC-S157 DBCO (Dibenzocyclooctyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-249 Anti-TNFRSF8 (Brentuximab-HC-Y180)-DBCO-MMAF ADC Anti-TNFRSF8 antibody, Brentuximab variant, HC-Y180 DBCO (Dibenzocyclooctyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-588 Anti-TNFRSF8 (cAC10)-Mc-VC-PABC-MMAE ADC Anti-TNFRSF8 Antibody, cAC10 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-262 Anti-TNFRSF8 (Brentuximab-LC-E161)-DBCO-MMAF ADC Anti-TNFRSF8-antibody, Brentuximab variant, LC-E161 DBCO (Dibenzocyclooctyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-263 Anti-TNFRSF8 (Brentuximab-LC-K149)-DBCO-MMAF ADC Anti-TNFRSF8-antibody, Brentuximab variant, LC-K149 DBCO (Dibenzocyclooctyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-260 Anti-TNFRSF8 (Brentuximab-LC-N152)-DBCO-MMAF ADC Anti-TNFRSF8-antibody, Brentuximab variant, LC-N152 DBCO (Dibenzocyclooctyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-261 Anti-TNFRSF8 Brentuximab-LC-Q147)-DBCO-MMAF ADC Anti-TNFRSF8-antibody, Brentuximab variant, LC-Q147 DBCO (Dibenzocyclooctyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-259 Anti-TNFRSF8 (Brentuximab-LC-R142)-DBCO-MMAF ADC Anti-TNFRSF8-antibody, Brentuximab variant, LC-R142 DBCO (Dibenzocyclooctyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-340 Anti-TNFRSF8 (cAC10)-DIBO-doxorubicin ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 DIBO (dibenzylcyclooctynol) doxorubicin Inquiry
ADC-W-341 Anti-TNFRSF8 (cAC10)-VC-MMAE ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-342 Anti-TNFRSF8 (cAC10)-Mc-PABC-MMAE ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-343 Anti-TNFRSF8 (cAC10)-Mc-VC-MMAE ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 mc-VC (maleimidocaproyl-valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-344 Anti-TNFRSF8 (cAC10)-Mc-VC-PABC-MMAE ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-345 Anti-TNFRSF8 (cAC10)-VC-MMAF ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 VC (valine-citrulline) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-346 Anti-TNFRSF8 (cAC10)-VC-PABC-MMAE ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 VC-PABC (valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-355 Anti-TNFRSF8 (cAC10)-Mc-MMAF ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-356 Anti-CD30 receptorc (cAC10)-Mc-VC-PABC-MMAF ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAF (Monomethyl auristatin F) Inquiry
ADC-W-349 Anti-TNFRSF8 (CA10)-β-glucuronide-Camptothecin Analog ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 β-glucuronide linker Camptothecin Analog Inquiry
ADC-W-350 Anti-TNFRSF8 (CA10)-β-glucuronide-CBI Minor Groove Binder ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 β-glucuronide linker CBI Minor Groove Binder Inquiry
ADC-W-351 Anti-TNFRSF8 (CA10)-β-glucuronide-MMAE ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 β-glucuronide linker MMAE (Monomethyl auristatin E) Inquiry
ADC-W-352 Anti-TNFRSF8 (cCA10)-β-glucuronide-MMAF ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 β-glucuronide linker MMAF (Monomethyl auristatin F) Inquiry
ADC-W-353 Anti-TNFRSF8 (cCA10)-β-glucuronide-doxorubicin propyloxazoline (DPO) ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 β-glucuronide linker doxorubicin propyloxazoline (DPO) Inquiry
ADC-W-347 Anti-TNFRSF8 (hCA10)-α-glucuronide-MMAE ADC Chimeric Anti-TNFRSF8 Antibody, hcAC10 α-glucuronide MMAE (Monomethyl auristatin E) Inquiry
ADC-W-348 Anti-TNFRSF8 (hCA10)-α-glucuronide-MMAF ADC Chimeric Anti-TNFRSF8 Antibody, hcAC10 α-glucuronide MMAF (Monomethyl auristatin F) Inquiry
ADC-W-509 Anti-TNFRSF8 (Brentuximab)-VC-PABC-MMAE ADC Chimeric Anti-TNFRSF8 Antibody, Brentuximab VC-PABC(valine-citrulline-p-aminobenzylcarbamate) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-406 Anti-TNFRSF8 (cAC10)-DIBO-doxorubicin ADC Chimeric Anti-TNFRSF8 Antibody, Cac10 DIBO (dibenzylcyclooctynol) doxorubicin Inquiry
ADC-W-481 Anti-TNFRSF8 (cAC10)-VC-MMAE ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-482 Anti-TNFRSF8 (cAC10)-VC-MMAE ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-483 Anti-TNFRSF8 (cAC10)-VC-MMAE ADC Chimeric Anti-TNFRSF8 Antibody, cAC10 VC (valine-citrulline) MMAE (Monomethyl auristatin E) Inquiry
ADC-W-2343 Anti-TNFRSF8 (Brentuximab )-SMCC-DM1 ADC Chimeric Anti-TNFRSF8 IgG1-kappa antibody, Brentuximab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-2344 Anti-TNFRSF8 (Brentuximab )-SPDB-DM4 ADC Chimeric Anti-TNFRSF8 IgG1-kappa antibody, Brentuximab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-2345 Anti-TNFRSF8 (Brentuximab )-MC-MMAF ADC Chimeric Anti-TNFRSF8 IgG1-kappa antibody, Brentuximab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-2346 Anti-TNFRSF8 (Brentuximab )-MC-Vc-PAB-SN38 ADC Chimeric Anti-TNFRSF8 IgG1-kappa antibody, Brentuximab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-2347 Anti-TNFRSF8 (Brentuximab )-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Chimeric Anti-TNFRSF8 IgG1-kappa antibody, Brentuximab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
ADC-W-1886 Anti-TNFRSF8 (Iratumumab)-SMCC-DM1 ADC Human Anti-TNFRSF8 IgG1-kappa antibody, Iratumumab SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) Inquiry
ADC-W-1887 Anti-TNFRSF8 (Iratumumab)-SPDB-DM4 ADC Human Anti-TNFRSF8 IgG1-kappa antibody, Iratumumab SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) Inquiry
ADC-W-1888 Anti-TNFRSF8 (Iratumumab)-MC-MMAF ADC Human Anti-TNFRSF8 IgG1-kappa antibody, Iratumumab MC (maleimidocaproyl) MMAF Inquiry
ADC-W-1889 Anti-TNFRSF8 (Iratumumab)-MC-Vc-PAB-MMAE ADC Human Anti-TNFRSF8 IgG1-kappa antibody, Iratumumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE Inquiry
ADC-W-1890 Anti-TNFRSF8 (Iratumumab)-MC-Vc-PAB-SN38 ADC Human Anti-TNFRSF8 IgG1-kappa antibody, Iratumumab MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin) Inquiry
ADC-W-1891 Anti-TNFRSF8 (Iratumumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC Human Anti-TNFRSF8 IgG1-kappa antibody, Iratumumab MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA Inquiry
If you can’t find your product on this list? Please directly send email to

Online Inquiry
Name:
*Phone:
*E-mail Address:
*Products or Services Interested:
Company/Institution
Project Description:
*Verification Code:
Please input "biolabs"(case insensitive) as verification code.


Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.


Contact us
USA
 45-1 Ramsey Road, Shirley, NY 11967, USA
 Tel: 1-631-357-2254
 Fax: 1-631-207-8356
 Email:
Europe
Heidenkampsweg 58, 20097 Hamburg, Germany
 Tel: 44-207-097-1828
 Email:

Inquiry

Top