This product is comprised of an anti-CD3D monoclonal antibody (Teplizumab) labeled with iFluor 546. iFluor 546 is a yellow-fluorescent dye and it's excitation/emission is 556/573 nm.
TARGET
- Alternative Names
- CD3D; CD3d molecule, delta (CD3-TCR complex); CD3d antigen, delta polypeptide (TiT3 complex) , T3D; T-cell surface glycoprotein CD3 delta chain; CD3 delta; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta polypeptide (TiT3 complex); T3D; CD3-DELTA
- Overview
- The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.
ANTIBODY
- Overview
- Humanized Anti-CD3D IgG1-kappa antibody, Teplizumab
DYE
- Excitation⁄Emission (nm)
- 556/573
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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