Teplizumab-OGreen (ADC-FL-557)

This product is comprised of an anti-CD3D monoclonal antibody (Teplizumab) labeled with Oregon green. Oregon green is a green-fluorescent dye and it's excitation/emission is 501/526 nm.

 TARGET

  • Name
  • CD3D
  • Alternative Names
  • CD3D; CD3d molecule, delta (CD3-TCR complex); CD3d antigen, delta polypeptide (TiT3 complex) , T3D; T-cell surface glycoprotein CD3 delta chain; CD3 delta; OKT3, delta chain; CD3 antigen, delta subunit; T-cell receptor T3 delta chain; CD3d antigen, delta polypeptide (TiT3 complex); T3D; CD3-DELTA
  • Overview
  • The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined.

 ANTIBODY

  • Overview
  • Humanized Anti-CD3D IgG1-kappa antibody, Teplizumab
  • Generic name
  • Teplizumab
  • Species Reactivity
  • Human

 DYE

  • Name
  • Oregon green
  • Color
  • Green
  • Excitation⁄Emission (nm)
  • 501/526

For Research Use Only. NOT FOR CLINICAL USE.


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