NAA Services for Anti-Ezrin
Ezrin is a structural protein with an important role in signaling pathways and has been shown to promote cancer dissemination. At present, we are able to provide a full range of anti-ezrin marker services for disease diagnosis and therapeutic monitoring. Creative Biolabs assembles a strong team with experienced Ph.D. level scientists, well-trained technicians, and responsible project managers just in order to deliver the most suitable service according to your budget, timeline, and specific requirements. Our professional team is optimized to help you get a milestone development in your natural autoantibodies (NAA) project.
Background of Ezrin
Ezrin, encoded by the Vil2 gene, is a membrane-cytoskeleton crosslinking protein of ezrin/radixin/moesin (ERM) family. It regulates cell shape, polarity, motility, growth and provides a functional link between the plasma membrane and the cortical actin cytoskeleton of the cell. Ezrin shows specificity to certain tissues and cells and it is commonly expressed on the inner surface of the cell membrane with moesin and radixin and plays an important role in the maintenance of cellular morphology and survival. Moreover, it also participates in crucial signal transduction pathways. Activated C-terminal of ezrin is linked with actin protein cytoskeleton, and the N-terminal is bound to multiple types of transmembrane molecules. It is expressed in several human epithelial tumors, and its overexpression in some tumor tissues or cell lines is required for metastasis. Therefore, ezrin plays a key role in the movement, adhesion, and invasion of tumor cells.
Fig.1 Structure and activation process of Ezrin. (Song, et al., 2020)
The Role of Anti-Ezrin Antibody in Pancreatic Cancer
Pancreatic cancer (PC) has a high mortality rate because it is usually diagnosed when metastasis has already occurred. Ezrin is expressed in a variety of normal and neoplastic cells, including many types of epithelial, lymphoid and glial cells and plays important role in cell motility, invasion and tumor progression, especially crucial for metastasis. In PC, a high-level ezrin expression is associated with high metastatic potential and the membrane translocation of ezrin might play a role in the progression from borderline tumor to malignant transformation. When overexpressing or silencing the ezrin protein expression in the pancreatic cancer cell line MiaPaCa-2, it showed that changes in the ezrin protein level were correlated with changes in the formation of dynamic cell protrusions, motility, invasion and the ability of anchorage-independent growth, which are all tumor cells features. Based on these, it can be proposed that ezrin might promote invasion and metastasis in carcinogenesis by participating in the formation of cell protrusions and the enhancement of anchorage-independent growth. These processes may be attributed to the activation of the Erk1/2 pathway. Moreover, ezrin may participate in the early events of PC development and may promote its progression to the advanced stage. Thus, using anti-ezrin antibody to block ezrin function may have therapeutic effects that prevent disease progression.
What We Can Do About NAA?
NAAs are thought to arise naturally without actual antigen stimulation. With the well-established platforms and experienced scientists, we can provide comprehensive NAA services, from NAA detection, NAA profiling, to NAA epitope mapping. In addition, a wide spectrum of NAA products is also available for your choice. Our seasoned technology and one-stop pipeline can help you solve the confusion in every step of your project development, saving your time and cost.
With years of experience, Creative Biolabs can deliver a wide range of contract research services that are tailored to their individual requirements in terms of science, timelines, and cost. We provide a wide range of NAA products and custom services based on the requirements of the clients. For more information about our services, please feel free to contact us to discuss your specific requirements.
References:
- Song, Y.; et al. Ezrin mediates invasion and metastasis in tumorigenesis: A review. Frontiers in Cell and Developmental Biology. 2020, 1321.
- Seung, Do.Choi. Ezrin is an Essential Marker for Metastasis of Gynecologic Cancer. J Korean Soc Menopause. 2012, 18(2): 81-93.
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