17-AEP-GA (ADC-P-053)

ADCs Toxins, 17-AEP-GA belongs to the Geldanamycin family. It is an HSP90 inhibitor. 17-AEP-GA was shown to be a powerful inhibitor of cancer cell growth (IC50 below 100 nm). Its binding affinity to HSP90 was not significantly affected compated to Geldanamycin and other analogs while its water solubility was highly improved compated to 17-AAG. Reference: ZQ Tian et al. Bioorg. Med. Chem 2004 12:5317

Description
ADCs Toxins, 17-AEP-GA belongs to the Geldanamycin family. It is an HSP90 inhibitor. 17-AEP-GA was shown to be a powerful inhibitor of cancer cell growth (IC50 below 100 nm). Its binding affinity to HSP90 was not significantly affected compated to Geldanamycin and other analogs while its water solubility was highly improved compated to 17-AAG. Reference: ZQ Tian et al. Bioorg. Med. Chem 2004 12:5317

Classification
Hsp90 Inhibitors

Molecular Weight
642.78

Purity
95%

For Research Use Only. NOT FOR CLINICAL USE.

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