Anti-TM4SF1 ( clone 2A7A)-Mc-LP2 ADC (ADC-W-518)

This ADC product is comprised of an anti-TM4SF1 monoclonal antibody (clone 2A7A) conjugated via a Mc linker to LP2.
  • Antibody clone #
  • 2A7A
  • Similar to
  • 2A7A-LP2

 ADC Target

  • Name
  • TM4SF1
  • Alternative Names
  • TM4SF1;L6; M3s1
  • Target Entrez Gene ID
  • 17112
  • Overview
  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]

 ADC Antibody

  • Overview
  • Humanized Anti-Mouse TM4SF1 Antibody, clone # 2A7A
  • Clone #
  • 2A7A
  • Species Reactivity
  • Mouse

 ADC Linker

  • Name
  • Mc (maleimidocaproyl)
  • Description
  • Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

 ADC payload drug

  • Name
  • LP2 (chemical name mc-3377)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

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