What is Amino-PEG1-acid and its primary function?

Amino-PEG1-acid is a bifunctional linker molecule containing both amine and carboxylic acid groups. It is primarily used in bioconjugation, linking small molecules, peptides, or antibodies in drug development applications like ADCs.

Can Amino-PEG1-acid be used in multi-drug conjugates?

Yes, Amino-PEG1-acid can be incorporated into multi-drug ADCs by allowing the attachment of different cytotoxic payloads. This provides researchers with flexibility in designing complex therapeutic agents.

What type of chemical reactions is Amino-PEG1-acid typically involved in?

Amino-PEG1-acid participates in amide bond formation, linking molecules through its carboxylic acid and amine groups. It is widely used in peptide synthesis, drug conjugation, and bioconjugation strategies.

Can Amino-PEG1-acid be used in other bioconjugation applications beyond ADCs?

Yes, Amino-PEG1-acid can be used for attaching molecules in a variety of bioconjugation applications, including enzyme labeling, nanoparticle functionalization, and the synthesis of multifunctional probes.

What challenges may arise when using Amino-PEG1-acid in ADC development?

One challenge is optimizing the linker length to balance drug release and stability. If the PEG1 linker is too short or long, it may affect the pharmacodynamics of the ADC.

Amino-PEG1-acid (CAT#: ADC-L-283)

Amino-PEG1-acid is a non-cleavable linker for bio-conjugation that contains a NH2/Amine group and a COOH/Carboxylic Acid group linked through a linear PEG chain.

Product Information

CAS NO
144942-89-2

Description
Amino-PEG1-acid is a non-cleavable linker for bio-conjugation that contains a NH2/Amine group and a COOH/Carboxylic Acid group linked through a linear PEG chain.

Molecular Weight
133.1

Purity
95%

Formula
C5H11NO3

Group 1
NH2/Amine

Functional Group 1
NH2/Amine

PEG/Non-PEG
PEG

Cleavable/Non-cleavable
Non-cleavable

Group 2
COOH/Carboxylic Acid

Functional Group 2
COOH/Carboxylic Acid

Storage Condition
-20 ° C

Shipping
Ambient Temperature

Published Data

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Customer Reviews FAQ

Excellent

Amino-PEG1-acid served as an excellent linker in my ADC experiments, providing stability and reliable bio-conjugation that enhanced the delivery of the cytotoxic payload to the target cells.

Excellent

In our protein conjugation studies, Amino-PEG1-acid worked flawlessly as a non-cleavable linker. The PEG chain ensured solubility and flexibility, facilitating efficient coupling between biomolecules.

Excellent

I incorporated Amino-PEG1-acid into our ADC development pipeline, and it provided a robust non-cleavable linker that improved drug stability and target specificity in our assays.

Excellent

In ADC research, Amino-PEG1-acid demonstrated exceptional performance as a linker, allowing effective payload attachment while maintaining structural integrity throughout the experiments.

Excellent

I utilized Amino-PEG1-acid in antibody-drug conjugates, and it provided the necessary durability as a non-cleavable linker, ensuring that the drug remained attached until it reached its target.

Q: 1: What is Amino-PEG1-acid and its primary function?
A: Amino-PEG1-acid is a bifunctional linker molecule containing both amine and carboxylic acid groups. It is primarily used in bioconjugation, linking small molecules, peptides, or antibodies in drug development applications like ADCs.
Q: 2: Can Amino-PEG1-acid be used in multi-drug conjugates?
A: Yes, Amino-PEG1-acid can be incorporated into multi-drug ADCs by allowing the attachment of different cytotoxic payloads. This provides researchers with flexibility in designing complex therapeutic agents.
Q: 3: What type of chemical reactions is Amino-PEG1-acid typically involved in?
A: Amino-PEG1-acid participates in amide bond formation, linking molecules through its carboxylic acid and amine groups. It is widely used in peptide synthesis, drug conjugation, and bioconjugation strategies.
Q: 4: Can Amino-PEG1-acid be used in other bioconjugation applications beyond ADCs?
A: Yes, Amino-PEG1-acid can be used for attaching molecules in a variety of bioconjugation applications, including enzyme labeling, nanoparticle functionalization, and the synthesis of multifunctional probes.
Q: 5: What challenges may arise when using Amino-PEG1-acid in ADC development?
A: One challenge is optimizing the linker length to balance drug release and stability. If the PEG1 linker is too short or long, it may affect the pharmacodynamics of the ADC.

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