ADC Linkers

Creative Biolabs offers a variety of chemically versatile linker molecules to facilitate antibody-drug conjugate (ADC) development projects. All chemical linkers are of >95% purity and they are the basic building blocks for a successful ADC. Linkers facilitate the conjugation of ADC toxins to antibodies and in the meantime, they also dictate the release mechanism of an ADC. Proper linker selection will not only ease the process of obtaining the conjugate but also help enhance the chemical and serum stability of the ADC. Creative Biolabs carries a series of cleavable linkers (pH-sensitive linkers, disulfide linker, peptide linkers, β-glucuronide linkers), non-cleavable linkers, and intermediate linker modules. In the meantime, we also offer the services in the DrugLnk synthesis platform to prepare customized linkers with unique structures.

Related Services:
CatalogProduct nameCAS NOStructure Molecular WeightPurityData sheetInquiry
ADC-L-003 Fmoc-Val-Cit-PAB159858-22-7Fmoc-Val-Cit-PAB601.6995%Inquiry
ADC-L-004 Fmoc-Val-Cit-PAB-PNP863971-53-3Fmoc-Val-Cit-PAB-PNP766.895%Inquiry
ADC-L-005 Mc-Val-Cit-PABC-PNP159857-81-5Mc-Val-Cit-PABC-PNP737.7695%Inquiry
ADC-L-007 Val-Cit-PAB159857-79-1Val-Cit-PAB379.4595%Inquiry
ADC-L-008 MC-Val-Cit-PAB-PNP159857-81-5MC-Val-Cit-PAB-PNP737.77 95%Inquiry
ADC-L-016 SMCC64987-85-5SMCC334.3295%Inquiry
ADC-L-001(Ac)Phe-Lys(Alloc)-PABC-PNP(Ac)Phe-Lys(Alloc)-PABC-PNP689.7195%Inquiry
ADC-L-0026-Maleimidohexanoic acid N-hydroxysuccinimide ester55750-63-56-Maleimidohexanoic acid N-hydroxysuccinimide ester308.2995%Inquiry
ADC-L-006Val-cit-PAB-OH159857-79-1Val-cit-PAB-OH379.4595%Inquiry
ADC-L-009Phe-Lys(Trt)-PAB1116085-99-4Phe-Lys(Trt)-PAB640.8195%Inquiry
ADC-L-010Fmoc-Phe-Lys(Trt)-PABFmoc-Phe-Lys(Trt)-PAB863.0595%Inquiry
ADC-L-011Fmoc-Phe -Lys(Trt)-PAB-PNP1116086-09-9Fmoc-Phe
-Lys(Trt)-PAB-PNP1028.1595%Inquiry
ADC-L-012Ala-Ala-Asn-PAB TFA saltAla-Ala-Asn-PAB TFA salt95%Inquiry
ADC-L-013Fmoc-Ala-Ala-Asn-PAB-PNPFmoc-Ala-Ala-Asn-PAB-PNP95%Inquiry
ADC-L-014Fmoc-Gly3-Val-Cit-PABFmoc-Gly3-Val-Cit-PAB95%Inquiry
ADC-L-015Fmoc-Gly3-Val-Cit-PAB-PNPFmoc-Gly3-Val-Cit-PAB-PNP95%Inquiry
ADC-L-017Py-ds-Prp-OsuPy-ds-Prp-Osu312.3695%Inquiry
ADC-L-018Py-ds-dmBut-OsuPy-ds-dmBut-Osu326.3995%Inquiry
ADC-L-019Py-ds-dmBut-OPFPPy-ds-dmBut-OPFP423.4295%Inquiry
ADC-L-020Py-ds-Prp-OPFPPy-ds-Prp-OPFP381.3495%Inquiry
ADC-L-021MAL-HA-OsuMAL-HA-Osu308.2995%Inquiry
ADC-L-022MEL-di-EG-OPFPMEL-di-EG-OPFP423.2995%Inquiry
ADC-L-023MEL-tri-EG-OPFPMEL-tri-EG-OPFP467.3495%Inquiry
ADC-L-024MEL-tetra-EG-OPFPMEL-tetra-EG-OPFP511.3995%Inquiry
ADC-L-025BCOT-di-EG-OPFPBCOT-di-EG-OPFP519.4695%Inquiry
ADC-L-026BCOT-tri-EG-OPFPBCOT-tri-EG-OPFP563.5195%Inquiry
ADC-L-027BCOT-tetra-EG-OPFPBCOT-tetra-EG-OPFP607.5695%Inquiry
ADC-L-028N3-di-EG-OPFPN3-di-EG-OPFP369.2495%Inquiry
ADC-L-029N3-tri-EG-OPFPN3-tri-EG-OPFP413.395%Inquiry
ADC-L-030N3-tetra-EG-OPFPN3-tetra-EG-OPFP457.3595%Inquiry
ADC-L-031ALD-BZ-OsuALD-BZ-Osu247.295%Inquiry
ADC-L-032ALD-di-EG-OsuALD-di-EG-Osu406.3995%Inquiry
ADC-L-033ALD-tetra-EG-OsuALD-tetra-EG-Osu494.4995%Inquiry
ADC-L-034ALD-di-EG-OPFPALD-di-EG-OPFP475.3695%Inquiry
ADC-L-035ALD-tetra-EG-OPFPALD-tetra-EG-OPFP563.4795%Inquiry
ADC-L-036PHA-di-EG-OPFPPHA-di-EG-OPFP489.3595%Inquiry
ADC-L-037PHA-tetra-EG-OPFPPHA-tetra-EG-OPFP577.4595%Inquiry
ADC-L-038Val-Cit-PAB159857-79-1Val-Cit-PAB379.4595%Inquiry
ADC-L-039Phe-Lys(Fmoc)-PABPhe-Lys(Fmoc)-PAB620.7495%Inquiry
ADC-L-040Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP253863-34-2Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP802.8395%Inquiry
ADC-L-041Cbz‐Phe‐(Alloc)Lys‐PAB‐PNP159857-90-6Cbz‐Phe‐(Alloc)Lys‐PAB‐PNP781.8195%Inquiry
ADC-L-042Boc‐Phe‐(Alloc)Lys‐PAB‐PNP1160844-44-9Boc‐Phe‐(Alloc)Lys‐PAB‐PNP747.7995%Inquiry
ADC-L-0434-((S)-2-((S)-2-amino-3- methylbutanamido)-5- ureidopentanamido)benzyl 2-(pyridin- 2-yldisulfanyl)ethylcarbamate1610769-13-54-((S)-2-((S)-2-amino-3-
methylbutanamido)-5-
ureidopentanamido)benzyl 2-(pyridin-
2-yldisulfanyl)ethylcarbamate591.7595%Inquiry
ADC-L-044N-Succinimidyl 3-(pyridin-2-yldithio)-propionate (SPDP)68181‐17‐9N-Succinimidyl 3-(pyridin-2-yldithio)-propionate (SPDP)312.3695%Inquiry
ADC-L-045perfluorophenyl 3-(pyridin-2-yldisulfanyl)propanoate160580-70-1perfluorophenyl 3-(pyridin-2-yldisulfanyl)propanoate381.3495%Inquiry
ADC-L-0462,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate107348-47-02,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)butanoate326.3995%Inquiry
ADC-L-0472,5-dioxopyrrolidin-1-yl 3-methyl-3-(pyridin-2-yldisulfanyl)butanoate2,5-dioxopyrrolidin-1-yl 3-methyl-3-(pyridin-2-yldisulfanyl)butanoate340.4295%Inquiry
ADC-L-048N-Succinimidyl 4-(2-pyridyldithio)butanoate115088-06-7N-Succinimidyl 4-(2-pyridyldithio)butanoate326.3995%Inquiry
ADC-L-0492,5-Dioxo-1-(4-(pyridin-2-yldisulfanyl)butanoyloxy)pyrrolidine-3-sulfonic acid1628113-16-52,5-Dioxo-1-(4-(pyridin-2-yldisulfanyl)butanoyloxy)pyrrolidine-3-sulfonic acid406.4595%Inquiry
ADC-L-050perfluorophenyl 4-(pyridin-2-yldisulfanyl)butanoateperfluorophenyl 4-(pyridin-2-yldisulfanyl)butanoate395.3795%Inquiry
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