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- Anti-ACVR2B MAb (Clone 1)-iFluor® 450 Succinimidyl Ester
Anti-ACVR2B MAb (Clone 1)-iFluor® 450 Succinimidyl Ester (CAT#: WJY0-LS6300)
This product is comprised of an Human Anti-ACVR2B IgG1-lambda antibody (Clone 1) labeled with iFluor® 450 Succinimidyl Ester. iFluor® 450 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
- TARGET
- ANTIBODY
- DYE
- Name
- ACVR2B
- Alternative Names
- ACVR2B; activin A receptor; type IIB; activin receptor type-2B; ActR IIB; HTX4; ACTRIIB; ActR-IIB;
- Overview
- Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
- Overview
- Human Anti-ACVR2B IgG1-lambda antibody (Clone 1)
- Species Reactivity
- Human
- Name
- iFluor® 450 Succinimidyl Ester
- Color
- Green
- Excitation⁄Emission (nm)
- 451/502
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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Same Target
| CAT# | Product Name | Linker | Payload |
| ADC-W-652 | Anti-ACVR2B (Bimagrumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-654 | Anti-ACVR2B (Bimagrumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-653 | Anti-ACVR2B (Bimagrumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-655 | Anti-ACVR2B (Bimagrumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-651 | Anti-ACVR2B (Bimagrumab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
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