Anti-FLAG-SPDP-NCS ADC (ADC-W-585)

This ADC product is comprised of an anti-FLAG monoclonal antibody conjugated via a SPDP linker to NCS. The NCS is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis.

ADC Target

Name
FLAG

Alternative Names
flaG; flagellar protein FlaG

ADC Antibody

Overview
Anti-FLAG Antibody

Species Reactivity
Human

ADC Linker

Name
SPDP(N-succinimidyl 3-[2-pyridyldithio]-propionate)

Description
Disulfide Linkers, are extensively exploited as a chemically labile linkage. Since the release of disulﬁde-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulﬁde isomerase, or similar enzymes, drugs can be released.

ADC payload drug

Name
NCS

Description
Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus. It is a product naturally found as a complex of an enediyne chromophore and a 10-kDa protein and it can induce both single-and double-strand breaks in DNA.

For Research Use Only. NOT FOR CLINICAL USE.

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