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- Anti-GD2 MAb (Clone 1)-iFluor® 532 Succinimidyl Ester
Anti-GD2 MAb (Clone 1)-iFluor® 532 Succinimidyl Ester (CAT#: WJY0-LS13033)
- TARGET
- ANTIBODY
- DYE
- Name
- GD2
- Alternative Names
- Ganglioside GD2; GD2
- Overview
- GD2 is a disialoganglioside expressed in tumors of neuroectodermal origin (including human neuroblastoma and melanoma), and its expression in normal tissues (mainly human cerebellum and peripheral nerves) is highly restricted.
The relative tumor-specific expression of GD2 makes it a suitable target for immunotherapy using monoclonal antibodies or artificial T cell receptors. An example of such an antibody is hu14.18K322A, a monoclonal antibody. The anti-GD2 antibody is currently in phase II clinical trials for the treatment of previously untreated high-risk neuroblastoma and combined chemotherapy prior to stem cell transplantation and radiation therapy. A previous phase I clinical trial designed to reduce toxicity in patients with refractory or recurrent neuroblastoma found a safe dose and determined that common toxicity, especially pain, can be well controlled.
- Overview
- Chimeric Anti-GD2 IgG1-kappa antibody (Clone 1)
- Species Reactivity
- Human
- Name
- iFluor® 532 Succinimidyl Ester
- Color
- Green
- Excitation⁄Emission (nm)
- 537/560
- Detection method
- Fluorescent
Published Data
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Other Products
Same Target
| CAT# | Product Name | Linker | Payload |
| ADC-W-2010 | Anti-GD2 (Dinutuximab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-2007 | Anti-GD2 (Dinutuximab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| ADC-W-2009 | Anti-GD2 (Dinutuximab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-2008 | Anti-GD2 (Dinutuximab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-2011 | Anti-GD2 (Dinutuximab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
For Research Use Only. NOT FOR CLINICAL USE.
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