Anti-IL17A MAb (Clone 2)-iFluor® 350 Succinimidyl Ester
Anti-IL17A MAb (Clone 2)-iFluor® 350 Succinimidyl Ester (WJY0-LS774)
This product is comprised of an Humanized Anti-IL17A IgG1-kappa antibody (Clone 2) labeled with iFluor® 350 Succinimidyl Ester. iFluor® 350 Succinimidyl Ester is a Blue-fluorescent dye and it's excitation/emission is 345/450 nm.
TARGET
Name
IL17A
Alternative Names
IL17a
Overview
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.