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- Anti-IL5RA MAb (Clone 2)-iFluor® 350 Succinimidyl Ester
Anti-IL5RA MAb (Clone 2)-iFluor® 350 Succinimidyl Ester (CAT#: WJY0-LS1346)
This product is comprised of an Humanized Anti-IL5RA IgG1-kappa (Clone 2) labeled with iFluor® 350 Succinimidyl Ester. iFluor® 350 Succinimidyl Ester is a Blue-fluorescent dye and it's excitation/emission is 345/450 nm.
- TARGET
- ANTIBODY
- DYE
- Name
- IL5RA
- Alternative Names
- CD125; CDw125; IL-5 receptor subunit alpha; IL5R; Interleukin-5 receptor subunit alpha; CD antigen CD125; HSIL5R3; IL-5R-alpha; IL-5R subunit alpha; IL-5RA
- Overview
- The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.
- Overview
- Humanized Anti-IL5RA IgG1-kappa (Clone 2)
- Species Reactivity
- Human
- Name
- iFluor® 350 Succinimidyl Ester
- Color
- Blue
- Excitation⁄Emission (nm)
- 345/450
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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| CAT# | Product Name | Linker | Payload |
| ADC-W-1404 | Anti-IL5RA (Benralizumab)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| ADC-W-1402 | Anti-IL5RA (Benralizumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-1403 | Anti-IL5RA (Benralizumab)-MC-Vc-PAB-MMAE ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAE |
| ADC-W-1401 | Anti-IL5RA (Benralizumab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| ADC-W-1400 | Anti-IL5RA (Benralizumab)-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) |
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