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- Anti-SLITRK6-MMAE ADC
Anti-SLITRK6-MMAE ADC (CAT#: ADC-W-489)
This ADC product is comprised of an anti-SLITRK6 monoclonal antibody conjugated via a linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Similar to
- AGS15E
- Name
- SLITRK6
- Alternative Names
- SLITRK6; SLIT and NTRK-like family, member 6; DFNMYP; SLIT and NTRK-like protein 6; 4832410J21Rik; slit and trk like gene 6;
- Target Entrez Gene ID
- 84189
- Target UniProt ID
- Q9H5Y7
- Overview
- This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. This protein functions as a regulator of neurite outgrowth required for normal hearing and vision. Mutations in this gene are a cause of myopia and deafness.
- Overview
- Human Anti-SLITRK6 lgG2 Antibody
- Species Reactivity
- Human
- Name
- protease-cleavable linker
- Name
- MMAE (Monomethyl auristatin E)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
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Quick Links
Other Products
Same Target
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-435 | Anti-SLITRK6-Mc-VC-MMAE ADC | mc-VC (maleimidocaproyl-valine-citrulline) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-052 | Protein A-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-011 | anti-HIgG(Fc)Fab-C-MMAE ADC | Cleavable linkers | MMAE (Monomethyl auristatin E) |
| ADC-W-529 | Anti-F3-VC-MMAE ADC-6 | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-565 | Anti-EDNRB-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-AA-056 | Anti-MIgG-VC-MMAE ADC | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
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