This product is comprised of an anti-ACVR2B monoclonal antibody (Bimagrumab) labeled with iFluor 750. iFluor 750 is a near-IR-fluorescent dye and it's excitation/emission is 749/775 nm.
TARGET
- Alternative Names
- ACVR2B; activin A receptor, type IIB; activin receptor type-2B; ActR IIB; HTX4; ACTRIIB; ActR-IIB;
- Overview
- Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
ANTIBODY
- Overview
- Human Anti-ACVR2B IgG1-lambda antibody, Bimagrumab
DYE
- Excitation⁄Emission (nm)
- 749/775
- Detection method
- Fluorescent
For Research Use Only. NOT FOR CLINICAL USE.
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