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Capromab-PBlue (CAT#: ADC-FL-1530)

This product is comprised of an anti-FOLH1 monoclonal antibody (Capromab) labeled with Pacific blue. Pacific blue is a blue-fluorescent dye and it's excitation/emission is 410/455 nm.

  • TARGET
  • ANTIBODY
  • DYE
  • Name
  • FOLH1
  • Alternative Names
  • FOLH1; folate hydrolase (prostate-specific membrane antigen) 1; FOLH; glutamate carboxypeptidase 2; GCP2; GCPII; glutamate carboxylase II; glutamate carboxypeptidase II; NAALAD1; NAALAdase; PSM; PSMA; NAALADase I; membrane glutamate carboxypeptidase; cell
  • Overview
  • This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.
  • Overview
  • Murine Anti-FOLH1 IgG1-kappa antibody, Capromab
  • Generic name
  • Capromab
  • Species Reactivity
  • Human
  • Name
  • Pacific blue
  • Color
  • Blue
  • Excitation⁄Emission (nm)
  • 410/455

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform
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ADC-W-118 Anti-FOLH1-cytotoxin Compound A ADC-1 cytotoxin Compound A
ADC-W-1163 Anti-FOLH1 (Capromab)-MC-Vc-PAB-MMAE ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) MMAE
ADC-W-1160 Anti-FOLH1 (Capromab)-SMCC-DM1 ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
ADC-W-1162 Anti-FOLH1 (Capromab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-433 Anti-FOLH1-thioester-DM1 ADC-2 thioester DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)

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