DBCO-SS-NHS (CAT#: ADC-L-904)

A: DBCO-SS-NHS is used for bioconjugation, enabling the attachment of biomolecules, such as proteins or antibodies, to other molecules via amine-reactive NHS ester and azide-reactive DBCO groups, commonly in click chemistry applications.

A: The NHS ester in DBCO-SS-NHS reacts with primary amines, forming stable amide bonds, while the DBCO group allows azide-click reactions, enabling efficient conjugation without the need for copper catalysts.

A: DBCO-SS-NHS is widely used in bioconjugation, antibody labeling, and protein-protein interactions. It enables the attachment of biomolecules to surfaces or other molecules in various bioorthogonal chemistry applications

A: The disulfide (SS) bond in DBCO-SS-NHS allows for potential cleavability, enabling the release of conjugated molecules under reducing conditions, such as in intracellular environments, where reducing agents are present.

A: Creative Biolabs offers high-purity DBCO-SS-NHS with enhanced reactivity and stability, ensuring efficient and reproducible bioconjugation for a wide range of bioorthogonal chemistry applications.