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Glucopiericidin A (CAT#: ADC-P-093)
ADCs Toxins, Glucopiericidin A is a natural bioactive compound. Glucopiericidin A (GPA) interestingly alone did not inhibit filopodia protrusion, but synergistically inhibit protrusion with the mitochondrial respiration inhibitor, piericidin A (PA). These results suggested that GPA might inhibit glycolysis. GPA may therefore serve as a glucose transporter chemical probe. Simultaneous inhibition of both glycolysis and mitochondrial respiration dramatically decreased intracellular ATP levels, indicating that GPA inhibits ATP-dependent filopodia protrusion with PA. HCT-116: IC50=1,73 uM; PSN1 : IC50=>8,67 uM; T98G : IC50=>8,67 uM; A549 : IC50=0,87 uM (preliminary laboratory results). Journal of Antibiotics (1989), 42, 1734.
- Product Information
- CAS NO
- 108073-65-0
- Description
- ADCs Toxins, Glucopiericidin A is a natural bioactive compound. Glucopiericidin A (GPA) interestingly alone did not inhibit filopodia protrusion, but synergistically inhibit protrusion with the mitochondrial respiration inhibitor, piericidin A (PA). These results suggested that GPA might inhibit glycolysis. GPA may therefore serve as a glucose transporter chemical probe. Simultaneous inhibition of both glycolysis and mitochondrial respiration dramatically decreased intracellular ATP levels, indicating that GPA inhibits ATP-dependent filopodia protrusion with PA. HCT-116: IC50=1,73 uM; PSN1 : IC50=>8,67 uM; T98G : IC50=>8,67 uM; A549 : IC50=0,87 uM (preliminary laboratory results). Journal of Antibiotics (1989), 42, 1734.
- Classification
- Others
- Molecular Weight
- 577.71
- Purity
- 95%
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