Anti-ST8SIA1 (Mitumomab)-MC-Vc-PAB-SN38 ADC (ADC-W-1782)

 ADC Target

  • Name
  • ST8SIA1
  • Alternative Names
  • ST8SIA1; ST8 alpha-N-acetyl-neuraminide alpha-2, 8-sialyltransferase 1; sialyltransferase 8 (alpha N acetylneuraminate: alpha 2, 8 sialytransferase, GD3 synthase) A , SIAT8, SIAT8A; alpha-N-acetylneuraminide alpha-2, 8-sialyltransferase; ST8Sia I; ganglioside GD3 synthase; ganglioside GT3 synthase; sialytransferase St8Sia I; alpha-2, 8-sialyltransferase 8A; disialoganglioside (GD3) synthase; ganglioside-specific alpha-2, 8-polysialyltransferase; sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2, 8-sialytransferase, GD3 synthase) A; sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2, 8-sialyltransferase, GD3 synthase); GD3S; SIAT8; SIAT8A; SIAT8-A; ST8SiaI;
  • Target Entrez Gene ID
  • 6489
  • Overview
  • Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene.

 ADC Antibody

  • Overview
  • Humanized Anti-ST8SIA1 IgG2b-kappa antibody, Mitumomab
  • Generic name
  • Mitumomab
  • Host animal
  • Mouse

 ADC Linker

  • Name
  • MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

 ADC payload drug

  • Name
  • SN-38 (7-ethyl-10-hydroxycamptothecin)
  • Description
  • SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1.

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