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PRO 140-Cy3 (CAT#: ADC-FL-356)

This product is comprised of an anti-CCR5 monoclonal antibody (PRO 140) labeled with Cy3. Cy3 is a orange-fluorescent dye and it's excitation/emission is 554/568 nm.

  • TARGET
  • ANTIBODY
  • DYE
  • Name
  • CCR5
  • Alternative Names
  • CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); chemokine (C C motif) receptor 5 , CMKBR5; C-C chemokine receptor type 5; CC CKR 5; CD195; CKR 5; CKR5; IDDM22; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A; CCR-5; CKR-5; CCCKR5; CMKBR5; CC-CKR-5; FLJ78003;
  • Overview
  • This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene.
  • Overview
  • Humanized Anti-CCR5 IgG4 antibody, PRO 140
  • Generic name
  • PRO 140
  • Species Reactivity
  • Human
  • Name
  • Cy3
  • Color
  • Orange
  • Excitation⁄Emission (nm)
  • 554/568
  • Detection method
  • Fluorescent

For Research Use Only. NOT FOR CLINICAL USE.

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ADC-W-769 Anti-CCR5 (PRO 140)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC MC-Vc-PAB-DMEA-(PEG2) duocarmycin SA
ADC-W-766 Anti-CCR5 (PRO 140)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
ADC-W-768 Anti-CCR5 (PRO 140)-MC-Vc-PAB-SN38 ADC MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) SN-38 (7-ethyl-10-hydroxycamptothecin)
ADC-W-764 Anti-CCR5 (PRO 140)-SMCC-DM1 ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
ADC-W-765 Anti-CCR5 (PRO 140)-SPDB-DM4 ADC SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)

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