NAA Services for Anti-COPS2 Antibody

Anti-COPS2 antibody is one of the identified serum natural autoantibodies (NAA) with potential for diagnosis and prognosis of gastric cancer. With abundant experience and first-in-class technologies, Creative Biolabs has developed a series of innovative NAA platforms, which enable us to successfully identify a wide range of NAA associated biomarkers for diseases diagnosis and therapeutic monitoring. Our professional team is proud to offer fast and convenient NAA services to help you get a milestone development in your NAA project.

Background of COPS2

COPS2, the abbreviation of COP9 (Constitutive photomorphogenesis 9) signalosome complex subunit 2, is an important component of COP9 signalosome complex (CSN). The major function of the CSN is to regulate protein degradation and participant in cellular and developmental processes by suppressing the activities of the cullin-RING-E3 ligases through deneddylation of cullins. In addition, CSN plays an essential role in transcriptional regulation, protein phosphorylation, and subcellular distribution. Especially, CSN is implicated in cancer genetics with its deneddylase activity to modulate the cellular concentration of oncogenic proteins such as IkB and TGFβ, suggesting the potential role as a prognostic biomarker of cancers. It is documented that knockdown of COPS2 will compromise the self-renewal and pluripotency of mouse embryonic stem cells (ESCs).

Fig.1 Structure of CSN. (Chung, 2015)

The Role of Anti-COPS2 in Gastric Cancer

Gastric cancer (GC) is the second leading cause of cancer-related deaths. Patients with advanced stage gastric cancer have extremely poor survival rates (< 15%), so accurate diagnosis and prognostic assessment are essential for optimizing therapeutic strategies, predicting the outcome of treatment, extending the survival period of patients, and potentially healing to reduce cancer mortality. Due to the potential diagnostic and prognostic applications, natural autoantibody (NAA)-based biomarkers attract particular interests. It is urgent to discover and identify novel NAA biomarkers to improve the sensitivity and specificity for the diagnosis of GC.

In human gastric cancer, anti-COPS2 is one of the identified serum autoantibodies with potential for diagnosis and prognosis. COPS2 can be recognized by autologous cytolytic T lymphocytes and can elicit humoral and cellular immune responses, leading to the production of anti-COPS2 autoantibodies. It has been suggested as an effective indicator for early detection of GC, an effective target for some experimental engineered T-cell therapies and a possible target for cancer vaccine since it can provide a very sensitive assay and is more stable in serum than most other proteins or tumor-derived DNA biomarkers. Moreover, anti-COPS2 could also serve as independent predictors of the overall GC patient survival through prognosis analysis.

Fig.2 Proteomic profiles of breast tumors with a large-scale protein-protein interaction network. (Ryan, 2017)

What Can We Do?

Aided by our well-established platforms and experienced scientists, Creative Biolabs can offer anti-COPS2 autoantibodies detection and identification services. To provide further validation, the abundance of autoantibodies specific to the biomarker candidates is analyzed using different and suitable methods, such as Enzyme-Linked Immunosorbent Assay (ELISA), LIPS, WB and dot blot. In addition, high throughput methods with high flux and accuracy are also available for one-stop NAA service (NAA detection, NAA profiling, NAA epitope mapping, etc.). These methods include but not limited to autoantigen/autoantibody array and peptide array. A variety of off-the-peg NAA products are also available for your benefit.

Identification and detection of anti-COPS2 autoantibodies are of great clinical importance to help the early diagnosis before the cancer onset. Creative Biolabs is well-positioned to provide the largest portfolio of products and services about NAA. In addition, we also provide custom services to meet the client's specific demand. Please contact us for more information.

References:

Chung, D.; Dellaire, G. The role of the COP9 signalosome and neddylation in DNA damage signaling and repair. Biomolecules. 2015, 5(4): 2388-2416.
Ryan, C.J.; et al. A compendium of co-regulated protein complexes in breast cancer reveals collateral loss events. Cell systems. 2017, 5(4): 399-409.

For Research Use Only | Not For Clinical Use

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