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Anti-SLAMF6 (clone 26B7)-VC-MMAE ADC (ADC-W-308)

This ADC product is comprised of an anti-SLAMF6 monoclonal antibody (clone 26B7) conjugated via a VC linker to MMAE. The MMAE is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAE binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
  • Antibody clone #
  • 26B7

 ADC Target

  • Name
  • SLAMF6
  • Alternative Names
  • SLAMF6; SLAM family member 6; KALI; NTBA; CD352; KALIb; Ly108; SLAMF6; SF2000; NTBA receptor; NK-T-B-antigen; activating NK receptor; natural killer-, T-and B-cell antigen;
  • Target Entrez Gene ID
  • 114836
  • Overview
  • The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

 ADC Antibody

  • Overview
  • Anti-SLAMF6 antibody, clone # 26B7
  • Clone #
  • 26B7
  • Host animal
  • Mouse
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • VC (valine-citrulline)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

 ADC payload drug

  • Name
  • MMAE (Monomethyl auristatin E)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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