- Home
- Products
- Customized ADCs
- SLAMF6
- Anti-SLAMF6-Mc-MMAF ADC-1
Anti-SLAMF6-Mc-MMAF ADC-1 (CAT#: ADC-W-307)
This ADC product is comprised of an anti-SLAMF6 monoclonal antibody (clone 11A1) conjugated via a Mc linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- 11A1
- Name
- SLAMF6
- Alternative Names
- SLAMF6; SLAM family member 6; KALI; NTBA; CD352; KALIb; Ly108; SLAMF6; SF2000; NTBA receptor; NK-T-B-antigen; activating NK receptor; natural killer-, T-and B-cell antigen;
- Target Entrez Gene ID
- 114836
- Target UniProt ID
- Q96DU3
- Overview
- The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
- Overview
- Anti-SLAMF6 antibody, clone # 11A1
- Clone #
- 11A1
- Host animal
- Mouse
- Species Reactivity
- Human
- Name
- Mc (maleimidocaproyl)
- Description
- Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Name
- MMAF (Monomethyl auristatin F)
- Description
- Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-CEACAM8 (Besilesomab)-SMCC-DM1 ADC (CAT#: ADC-W-2204)
- Anti-CD74-hindered disulfide-Doxorubicin ADC (CAT#: ADC-W-378)
- Anti-ITGB3 (Tadocizumab)-MC-MMAF ADC (CAT#: ADC-W-2606)
- Anti-CD70-Mc-VC-PBD ADC-5 (CAT#: ADC-W-446)
- Anti-SDC1 (Indatuximab )-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-2514)
- Anti-CD74-VC-MMAE ADC-1 (CAT#: ADC-W-036)
- Anti-EGFR (Matuzumab)-SMCC-DM1 ADC (CAT#: ADC-W-1034)
- Anti-TNFRSF9 (Urelumab)-SMCC-DM1 ADC (CAT#: ADC-W-1892)
- Anti-NCA-90 (Lemalesomab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-2165)
- Anti-CD79B (Polatuzumab )-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-2559)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-307. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-309 | Anti-SLAMF6-Mc-MMAF ADC-2 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-308 | Anti-SLAMF6-VC-MMAE ADC-2 | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| ADC-W-306 | Anti-SLAMF6-VC-MMAE ADC-1 | VC (valine-citrulline) | MMAE (Monomethyl auristatin E) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-478 | Anti-ENPP3-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-485 | Anti-EphA2-Mc-MMAF ADC-1 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-452 | Anti-CD70-Mc-MMAF ADC-1 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-493 | Anti-CD19-Mc-MMAF ADC-3 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-515 | Anti-EGFR-Mc-MMAF ADC-5 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-604 | Anti-FUT3-Mc-VC-PABC-MMAF ADC-3 | MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | MMAF (Monomethyl auristatin F) |
| ADC-AA-002 | anti-HIgG(Fc)-C-MMAF ADC | Cleavable linkers | MMAF (Monomethyl auristatin F) |
| ADC-W-537 | Anti-TPBG-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-AA-049 | Protein G-MMAF ADC | MMAF (Monomethyl auristatin F) | |
| ADC-W-515 | Anti-EGFR-Mc-MMAF ADC-5 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
