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Anti-GUCY2C (clone 5F9)-Mc-MMAF ADC (ADC-W-210)

This ADC product is comprised of an anti-GUCY2C monoclonal antibody (clone 5F9) conjugated via a Mc linker to MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
  • Antibody clone #
  • 5F9

 ADC Target

  • Name
  • GUCY2C
  • Alternative Names
  • GUCY2C; guanylate cyclase 2C; STAR; DIAR6; GUC2C; MECIL; MUCIL; heat-stable enterotoxin receptor; GC-C; hSTAR; STA receptor; guanylyl cyclase C; intestinal guanylate cyclase; heat stable enterotoxin receptor;
  • Target Entrez Gene ID
  • 2984
  • Overview
  • Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene.
    Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain. The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.

 ADC Antibody

  • Overview
  • Anti-GUCY2C antibody, clone # 5F9
  • Clone #
  • 5F9
  • Species Reactivity
  • Human

 ADC Linker

  • Name
  • Mc (maleimidocaproyl)
  • Description
  • Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.

 ADC payload drug

  • Name
  • MMAF (Monomethyl auristatin F)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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