Anti-DLL3-D6.5 ADC (ADC-W-498)

This ADC product is comprised of an anti-DLL3 monoclonal antibody conjugated via a linker to D6.5.
  • Similar to
  • SC16LD6.5(rovalpituzumab tesirine)

 ADC Target

  • Name
  • DLL3
  • Alternative Names
  • DLL3; delta-like 3 (Drosophila); SCDO1; delta-like protein 3; delta3; drosophila Delta homolog 3;
  • Target Entrez Gene ID
  • 10683
  • Overview
  • This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

 ADC Antibody

  • Overview
  • Anti-DLL3 Antibody
  • Species Reactivity
  • Human

 ADC payload drug

  • Name
  • D6.5
  • Description
  • Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

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