Anti-DLL3-D6.5 ADC (ADC-W-498)

This ADC product is comprised of an anti-DLL3 monoclonal antibody conjugated via a linker to D6.5.

Alternative Names
DLL3; delta-like 3 (Drosophila); SCDO1; delta-like protein 3; delta3; drosophila Delta homolog 3;

Overview
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

Description
Pyrrolobenzodiazepine (PBD) dimmers are highly cytotoxic DNA cross-linking agents. PBDs exert their biological activity through covalent binding via their N10-C11imine/carbinolamine moieties to the C2-amino position of a guanine residue within the minor groove of DNA.

For Research Use Only. NOT FOR CLINICAL USE.

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