Anti-IL13 MAb (Clone 11)-iFluor® 440 Succinimidyl Ester
Anti-IL13 MAb (Clone 11)-iFluor® 440 Succinimidyl Ester (WJY0-LS5924)
This product is comprised of an Human Anti-IL13 IgG4-kappa (Clone 11) labeled with iFluor® 440 Succinimidyl Ester. iFluor® 440 Succinimidyl Ester is a Green-fluorescent dye and it's excitation/emission is 403/427 nm.
TARGET
Name
IL13
Alternative Names
Interleukin-13; P600; IL-13
Overview
This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4.