What is Epothilone A, and how is it used in research?

Epothilone A is a natural product that stabilizes microtubules, similar to paclitaxel. It is commonly used in cancer research to study cell division and apoptosis, making it a potential payload in ADCs.

What advantages does Epothilone A offer over other microtubule stabilizers in ADCs?

Epothilone A shows activity against tumors that are resistant to other microtubule-stabilizing agents like paclitaxel, making it a valuable alternative in ADC payload design.

What are the primary side effects of using Epothilone A in preclinical studies?

Common side effects in preclinical models include neuropathy and cytotoxicity in non-target tissues. However, these effects can be mitigated in ADCs through targeted delivery to tumor cells.

Can Epothilone A be used in drug-resistant cancer models?

Yes, Epothilone A has shown efficacy in models of drug-resistant cancers, including those resistant to paclitaxel, due to its ability to bind distinct sites on tubulin.

Is Epothilone A suitable for use in immuno-oncology research?

While primarily a cytotoxic agent, Epothilone A can be integrated into immuno-oncology strategies, particularly in ADCs targeting tumor-associated antigens for enhanced cancer cell elimination.

Epothilone A (CAT#: ADC-P-048)

ADCs Toxins, Epothilone A exhibits kinetics similar to paclitaxel by inducing tubulin polymerization in vitro and producing enhanced microtubule stability and bundling in cultured cells. In contrast to paclitaxel, Epothilone A exhibits a greater cytotoxicity against P-glycoprotein-expressing multidrug resistant cells (IC50= 20 nM for MDR CCRF-CEM/VBL100 cells).Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 µM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to epothilone B.

Product Information

Description
ADCs Toxins, Epothilone A exhibits kinetics similar to paclitaxel by inducing tubulin polymerization in vitro and producing enhanced microtubule stability and bundling in cultured cells. In contrast to paclitaxel, Epothilone A exhibits a greater cytotoxicity against P-glycoprotein-expressing multidrug resistant cells (IC50= 20 nM for MDR CCRF-CEM/VBL100 cells).Epo A is cytotoxic to human T-24 bladder carcinoma cells (IC50 = 0.05 µM in vitro) but has poor pharmacological properties and is 2-fold less potent in stabilizing microtubules compared to epothilone B.

Classification
Microtubule Inhibitors

Molecular Weight
493.7

Purity
95%

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Customer Reviews FAQ

Excellent

Epothilone A proved to be an effective compound in our cancer cell assays, particularly showing significant cytotoxicity against T-24 bladder carcinoma cells. Its tubulin polymerization ability was impressive in stabilizing microtubules.

Excellent

In our ADC research, Epothilone A was an exceptional cytotoxic agent. Its ability to target multidrug-resistant cells made it invaluable in enhancing the efficacy of antibody-drug conjugates.

Excellent

When using Epothilone A in ADC development, its cytotoxic effects were apparent, especially against multidrug-resistant cells. The compound showed promise in enhancing drug delivery systems for targeted therapies.

Excellent

I tested Epothilone A in multidrug-resistant cell lines and observed superior cytotoxic effects compared to paclitaxel. This compound is especially potent against cells expressing P-glycoprotein.

Excellent

Our lab employed Epothilone A in ADC experiments, and its efficacy against MDR cells was impressive. Its microtubule-stabilizing properties made it an ideal choice for our conjugate development.

Q: 1: What is Epothilone A, and how is it used in research?
A: Epothilone A is a natural product that stabilizes microtubules, similar to paclitaxel. It is commonly used in cancer research to study cell division and apoptosis, making it a potential payload in ADCs.
Q: 2: What advantages does Epothilone A offer over other microtubule stabilizers in ADCs?
A: Epothilone A shows activity against tumors that are resistant to other microtubule-stabilizing agents like paclitaxel, making it a valuable alternative in ADC payload design.
Q: 3: What are the primary side effects of using Epothilone A in preclinical studies?
A: Common side effects in preclinical models include neuropathy and cytotoxicity in non-target tissues. However, these effects can be mitigated in ADCs through targeted delivery to tumor cells.
Q: 4: Can Epothilone A be used in drug-resistant cancer models?
A: Yes, Epothilone A has shown efficacy in models of drug-resistant cancers, including those resistant to paclitaxel, due to its ability to bind distinct sites on tubulin.
Q: 5: Is Epothilone A suitable for use in immuno-oncology research?
A: While primarily a cytotoxic agent, Epothilone A can be integrated into immuno-oncology strategies, particularly in ADCs targeting tumor-associated antigens for enhanced cancer cell elimination.

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