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- Anti-IL13RA2-Mc- ADC
Anti-IL13RA2-Mc- ADC (CAT#: ADC-W-010)
This ADC product is comprised of an anti- IL13RA2 monoclonal antibody (clone hu08) conjugated via a Mc linker to a drug.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- Antibody clone #
- hu08
- Name
- IL13RA2
- Alternative Names
- CT19; IL-13R; IL13BP; CD213A2
- Target Entrez Gene ID
- 3598
- Target UniProt ID
- Q14627
- Overview
- The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13.
- Overview
- Humanized Anti-IL13RA2 antibody, clone # hu08
- Clone #
- hu08
- Species Reactivity
- Human
- Name
- Mc (maleimidocaproyl)
- Description
- Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
For Research Use Only. NOT FOR CLINICAL USE.
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Published Data
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Quick Links
Other Products
Same Target
Same Linker
| CAT# | Product Name | Linker | Payload |
| ADC-W-009 | Anti-IL13RA2-MalPeg ADC | MalPeg |
| CAT# | Product Name | Linker | Payload |
| ADC-W-491 | Anti-TNFRSF17-Mc-MMAF ADC | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-515 | Anti-EGFR-Mc-MMAF ADC-5 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-114 | Anti-CD33-Mc-MMAF ADC-3 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-115 | Anti-CD33-Mc-MMAF ADC-1 | Mc (maleimidocaproyl) | MMAF (Monomethyl auristatin F) |
| ADC-W-518 | Anti-TM4SF1-Mc-LP2 ADC-2 | Mc (maleimidocaproyl) | LP2 (chemical name mc-3377) |
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