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Anti-CXCR4 (ulocuplumab)-pAcF-MMAF ADC (CAT#: ADC-W-386)

This ADC product is comprised of an anti-CXCR4 monoclonal antibody (ulocuplumab) conjugated via a pAcF linker to a MMAF. The MMAF is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, MMAF binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.

  • ADC Target
  • ADC Antibody
  • ADC Linker
  • ADC payload drug
  • Name
  • CXCR4
  • Alternative Names
  • CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y rece
  • Target Entrez Gene ID
  • 7852
  • Overview
  • This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • Overview
  • Humanized Anti-CXCR4 lgG4 Antibody, ulocuplumab
  • Generic name
  • ulocuplumab
  • Species Reactivity
  • Human
  • Name
  • p-acetyl phenylalanine (pAcF)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Name
  • MMAF (Monomethyl auristatin F)
  • Description
  • Derived from Auristatin,are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

For Research Use Only. NOT FOR CLINICAL USE.

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CAMouse™-Fully Human Antibody Generation Platform
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ADC-W-1924 Anti-CXCR4 (Ulocuplumab)-MC-MMAF ADC MC (maleimidocaproyl) MMAF
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ADC-W-1922 Anti-CXCR4 (Ulocuplumab)-SMCC-DM1 ADC SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) DM1 (N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine)
ADC-W-520 Anti-CXCR4-dasatinib ADC disulfide-cleavable linkers dasatinib
ADC-W-519 Anti-CXCR4-PEG-S-4FB-dasatinib ADC PEG-S-4FB linker dasatinib
CAT# Product Name Linker Payload
ADC-AA-053 Protein A-MMAF ADC MMAF (Monomethyl auristatin F)
ADC-W-491 Anti-TNFRSF17-Mc-MMAF ADC Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-AA-001 anti-HIgG(Fc)-N-MMAF ADC Noncleavable linkers MMAF (Monomethyl auristatin F)
ADC-W-515 Anti-EGFR-Mc-MMAF ADC-5 Mc (maleimidocaproyl) MMAF (Monomethyl auristatin F)
ADC-AA-049 Protein G-MMAF ADC MMAF (Monomethyl auristatin F)

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