- Home
- Products
- Customized ADCs
- MUC1
- Anti-MUC1-PEG4Mal-DM1 ADC-4
Anti-MUC1-PEG4Mal-DM1 ADC-4 (CAT#: ADC-W-313)
This ADC product is comprised of an anti-MUC1 monoclonal antibody (clone huC242) conjugated via a PEG4Mal linker to a DM1. The DM1 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, DM1 binds to tubulins, interrupts microtubule dynamics, and subsequently, induces cell death.
- Product Information
- ADC Target
- ADC Antibody
- ADC Linker
- ADC payload drug
- Antibody clone #
- huC242
- Name
- MUC1
- Alternative Names
- MUC1; mucin 1, cell surface associated; EMA; MCD; PEM; PUM; KL-6; MAM6; MCKD; PEMT; CD227; H23AG; MCKD1; MUC-1; ADMCKD; ADMCKD1; CA 15-3; MUC-1/X; MUC1/ZD; MUC-1/SEC; mucin-1; episialin; DF3 antigen; H23 antigen; cancer antigen 15-3; krebs von den Lungen-
- Target Entrez Gene ID
- 4582
- Target UniProt ID
- P15941
- Overview
- The CanAg tumour antigen is a novel glycoform of MUC1.
- Overview
- Humanized Anti-MUC1 lgG1 antibody, clone # huC242
- Clone #
- huC242
- Species Reactivity
- Human
- Name
- PEG4Mal
- Name
- DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine)
- Description
- Derived from Maytansinoid,a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.
For Research Use Only. NOT FOR CLINICAL USE.
Related Products
- Anti-ERBB3 (Duligotuzumab)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC (CAT#: ADC-W-2371)
- Anti-RTN4 (Atinumab)-MC-MMAF ADC (CAT#: ADC-W-1738)
- Anti-CD79B (Polatuzumab)-Mc-VC-PABC-MMAE ADC (CAT#: ADC-W-380)
- Anti-LOXL2 (Simtuzumab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-1529)
- Anti-ITGA4 (Etrolizumab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-1475)
- Anti-IL12+IL23 (Ustekinumab)-MC-Vc-PAB-SN38 ADC (CAT#: ADC-W-1956)
- Anti-CD28 (lumretuzumab)-SPDB-DM4 ADC (CAT#: ADC-W-2277)
- Anti-TNFRSF13B (Belimumab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-1913)
- Anti-CD70-VC-MMAE ADC-1 (CAT#: ADC-W-080)
- Anti-PCSK9 (Bococizumab)-MC-Vc-PAB-MMAE ADC (CAT#: ADC-W-2231)
Published Data
+ Submit Publications
Scientific Resources
Customer Reviews and FAQs
There are currently no Customer reviews or questions for ADC-W-313. Click the button above to contact us or submit your feedback about this product.
Quick Links
Other Products
Same Target
Same Linker
Same Payload
| CAT# | Product Name | Linker | Payload |
| ADC-W-2427 | Anti-MUC1 (Pemtumomab)-SPDB-DM4 ADC | SPDB (N-succinimidyl-4-(2-pyridyldithio)butyrate) | DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine) |
| ADC-W-2428 | Anti-MUC1 (Pemtumomab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-1633 | Anti-MUC1 (Nacolomab tafenatox)-MC-Vc-PAB-DMEA-(PEG2)-duocarmycin SA ADC | MC-Vc-PAB-DMEA-(PEG2) | duocarmycin SA |
| ADC-W-2488 | Anti-MUC1 (Sontuzumab)-MC-MMAF ADC | MC (maleimidocaproyl) | MMAF |
| ADC-W-1632 | Anti-MUC1 (Nacolomab tafenatox)-MC-Vc-PAB-SN38 ADC | MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl) | SN-38 (7-ethyl-10-hydroxycamptothecin) |
| CAT# | Product Name | Linker | Payload |
| ADC-W-396 | Anti-EpCAM-Mal-dPEG4-NHS-DM1 ADC-1 | PEG4Mal | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| CAT# | Product Name | Linker | Payload |
| ADC-AA-054 | Protein A-MCC-DM1 ADC | MCC (Maleimidomethyl cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-AA-026 | anti-MIgG(Fc)-N-DM1 ADC | Noncleavable linkers | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-496 | Anti-EGFR-SMCC-DM1 ADC | SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-AA-018 | anti-HIgG(Fab)-N-DM1 ADC | Noncleavable linkers | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
| ADC-W-460 | Anti-NCAM1-SPP-DM1 ADC | SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate) | DM1 (N2’-Deacetyl-N2’-(3-mercapto-1-oxopropyl)maytansine) |
Online Inquiry
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
