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Anti-NCA-90 (Lemalesomab)-MC-Vc-PAB-SN38 ADC (ADC-W-2166)

This ADC product is comprised of an anti-NCA-90 monoclonal antibody conjugated via a MC-Vc-PAB linker to SN38. The SN-38 is targeted to certain cancers by immunerecognition and delivered into cancer cells via receptor mediated endocytosis. Within the cell, SN-38 binds to DNA, causes DNA damage.

 ADC Target

  • Name
  • NCA-90
  • Alternative Names
  • NCA-90
  • Overview
  • One of the nonspecific cross-reacting antigens found to be expressed on a variety of cell types. In the nomenclature of CD antigens this protein has been given the designation CD66a. NCA-90 and NCA-50 have the same sequence and the same placement of glycosylation sites despite their differences in molecular masses.

 ADC Antibody

  • Overview
  • Humanized Anti-NCA-90 IgG1 antibody, Lemalesomab
  • Generic name
  • Lemalesomab
  • Host animal
  • Mouse

 ADC Linker

  • Name
  • MC-Vc-PAB (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
  • Description
  • Peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.

 ADC payload drug

  • Name
  • SN-38 (7-ethyl-10-hydroxycamptothecin)
  • Description
  • SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1.

For Research Use Only. NOT FOR CLINICAL USE.

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